Gene: DAXX
Official Full Name: death domain associated proteinprovided by HGNC
Gene Summary: This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00564 | DAXX Knockout cell line (HeLa) | Human | DAXX | 1:3~1:6 | Negative | Online Inquiry |
KO10878 | DAXX Knockout cell line (HCT 116) | Human | DAXX | 1:2~1:4 | Negative | Online Inquiry |
KO10879 | DAXX Knockout cell line (HEK293) | Human | DAXX | 1:3~1:6 | Negative | Online Inquiry |
KO10880 | DAXX Knockout cell line (A549) | Human | DAXX | 1:3~1:4 | Negative | Online Inquiry |
DAXX Gene Knockout Cell Lines are advanced cellular models engineered to entirely disrupt the expression of the DAXX (Death Domain Associated Protein) gene, which plays a crucial role in various cellular functions, including apoptosis, stress response, and chromatin remodeling. These models are created using targeted genome-editing technologies, such as CRISPR/Cas9 or RNA interference, to facilitate precise gene knockout, allowing researchers to study the downstream effects of DAXX absence in both normal and pathological states.
The key function of DAXX Gene Knockout Cell Lines lies in their ability to elucidate the diverse biological pathways regulated by DAXX. This knockout model enables researchers to dissect the molecular mechanisms involved in cellular differentiation, response to DNA damage, and tumorigenesis. Furthermore, these cell lines serve as invaluable tools in drug discovery and development, allowing scientists to evaluate therapeutic candidates' efficacy and specificity in a controlled environment devoid of DAXX activity.
In terms of scientific importance, DAXX Gene Knockout Cell Lines support a wide range of research applications, from cancer biology to neurobiology, thereby enhancing our understanding of diseases linked to dysfunctional DAXX signaling. Compared to traditional cell lines or less targeted genetic manipulation methods, these knockout models provide a higher level of specificity and reproducibility, yielding more reliable experimental results.
The unique selling point of our DAXX Gene Knockout Cell Lines is their validated use in diverse experimental settings, coupled with extensive characterization data to support various research needs. Researchers and clinicians can rest assured of consistent performance and high-quality data when incorporating these models into their studies.
Our commitment to advancing biological research reflects our expertise in providing cutting-edge cellular models. With a focus on rigorous validation and customer-centric support, we empower scientists to accelerate their research pursuits effectively and efficiently.
Please note that all services are for research use only. Not intended for any clinical use.
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