Gene: CTPS2
Official Full Name: CTP synthase 2provided by HGNC
Gene Summary: The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18488 | CTPS2 Knockout cell line (HeLa) | Human | CTPS2 | 1:3~1:6 | Negative | Online Inquiry |
KO18489 | CTPS2 Knockout cell line (HCT 116) | Human | CTPS2 | 1:2~1:4 | Negative | Online Inquiry |
KO18490 | CTPS2 Knockout cell line (HEK293) | Human | CTPS2 | 1:3~1:6 | Negative | Online Inquiry |
KO18491 | CTPS2 Knockout cell line (A549) | Human | CTPS2 | 1:3~1:4 | Negative | Online Inquiry |
CTPS2 Gene Knockout Cell Lines are precisely engineered cellular models designed to investigate the function and role of the CTPS2 gene, which encodes cytidine triphosphate synthase 2. These cell lines have been generated using cutting-edge CRISPR/Cas9 technology, ensuring specific and efficient disruption of the CTPS2 gene, thus providing a valuable tool for researchers studying nucleotide metabolism, cellular proliferation, and responses to pharmacological agents.
The primary function of CTPS2 is to catalyze the conversion of UTP to CTP, pivotal for the synthesis of nucleotides required for DNA and RNA production. By leveraging these knockout cell lines, researchers can elucidate the biochemical pathways influenced by the loss of CTPS2 function and explore its implications in various cellular processes, including growth regulation and apoptosis.
The significance of CTPS2 Gene Knockout Cell Lines extends across fundamental research and clinical applications. In academic settings, these models facilitate the investigation of metabolic diseases associated with nucleotide imbalance, while in pharmaceutical research, they represent a critical platform for drug discovery and toxicity testing, particularly for agents targeting proliferative diseases like cancer.
Unlike other cell lines, our CTPS2 knockout models demonstrate unparalleled specificity and reproducibility, reducing the risk of off-target effects, which is a common shortfall of conventional knockdown methodologies. Furthermore, they offer easy culturing and adaptability to various experimental conditions.
For researchers, clinicians, and biotech companies, the CTPS2 Gene Knockout Cell Lines are indispensable for advancing the understanding of cellular biology and therapeutic innovations. Our commitment to quality and precision in bioresearch products is founded on years of expertise in genetic engineering and cell biology. By choosing our product, users are equipped with a unique resource that not only enhances their research capabilities but also contributes significantly to the advancement of biomedical science.
Please note that all services are for research use only. Not intended for any clinical use.
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