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CSNK2A2 Knockout Cell Lines

Gene: CSNK2A2

Official Full Name: casein kinase 2 alpha 2provided by HGNC

Gene Summary: This gene encodes the alpha', or alpha 2, catalytic subunit of the protein kinase enzyme, casein kinase 2 (CK2). Casein kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. This heterotetrameric kinase includes two catalytic subunits, either alpha or alpha', and two regulatory beta subunits. The closely related gene paralog encoding the alpha, or alpha 1 subunit (CSNK2A1, Gene ID: 1457) is found on chromosome 20. An intronic variant in this gene (alpha 2) may be associated with leukocyte telomere length in a South Asian population. A related transcribed pseudogene is found on chromosome 11. [provided by RefSeq, Aug 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11100 CSNK2A2 Knockout cell line (HeLa) Human CSNK2A2 1:3~1:6 Negative Online Inquiry
KO11101 CSNK2A2 Knockout cell line (HCT 116) Human CSNK2A2 1:2~1:4 Negative Online Inquiry
KO11102 CSNK2A2 Knockout cell line (HEK293) Human CSNK2A2 1:3~1:6 Negative Online Inquiry
KO11103 CSNK2A2 Knockout cell line (A549) Human CSNK2A2 1:3~1:4 Negative Online Inquiry

Background

CSNK2A2 Gene Knockout Cell Lines are specifically engineered cellular models lacking expression of the CSNK2A2 gene, which encodes the alpha-2 subunit of casein kinase 2 (CK2). This cell line serves as a powerful tool for researchers aiming to investigate the biological role of CK2 in various cellular processes, including cell proliferation, apoptosis, and the modulation of signaling pathways. By knocking out this gene, the lines facilitate the study of CK2's function in disease mechanisms, particularly in cancer and neurodegenerative disorders.

The primary function of the CSNK2A2 knockout cells is to provide insights into the downstream effects of CK2 signaling. Without the expression of the alpha-2 subunit, researchers can assess changes in cellular behavior, including alterations in protein phosphorylation patterns and gene expression profiles. This enables the elucidation of CK2's involvement in key biological processes. The unique mechanism they provide will help clarify pathway interdependencies and might unveil novel therapeutic targets.

Scientifically, CSNK2A2 gene knockout cell lines play a critical role in advancing our understanding of CK2's implications in health and disease. These models can be utilized in various research applications, from drug discovery to functional genomics, making them invaluable in academic and clinical settings.

One of the significant advantages of our CSNK2A2 knockout cell lines is their specificity and reliability compared to alternative models, such as pharmacological inhibition, which may produce off-target effects. Unlike transient knockdown approaches that may lack stability, our knockout cell lines offer a robust platform for generating consistent results over extended experimental periods.

The inherent value of our CSNK2A2 knockout cell lines lies in their ability to empower researchers and clinicians with precise and nuanced insights into CK2-related pathways, paving the way for innovative discoveries and potential therapeutic interventions. With a commitment to excellence in biological research tools, our company combines scientific expertise with unparalleled product quality, ensuring that you have access to the most effective tools for advancing your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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