Gene: CSNK1A1
Official Full Name: casein kinase 1 alpha 1provided by HGNC
Gene Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of signal transduction. Located in cytoskeleton; cytosol; and nucleus. Part of beta-catenin destruction complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01349 | CSNK1A1 Knockout cell line (HeLa) | Human | CSNK1A1 | 1:3~1:6 | Negative | Online Inquiry |
CSNK1A1 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the casein kinase 1 alpha 1 (CSNK1A1) protein's function and its implications in various biological processes. These knockout cell lines have been engineered through precise gene editing techniques, such as CRISPR-Cas9, to ablate the expression of the CSNK1A1 gene. This targeted disruption allows researchers to investigate the consequential effects on cellular signaling pathways, gene expression profiles, and how these alterations can lead to disease phenotypes or affect cellular homeostasis.
The CSNK1A1 protein plays a crucial role in numerous cellular functions, including circadian rhythm regulation, cellular proliferation, and apoptosis. By utilizing the knockout cell lines, scientists can elucidate the intricate regulatory effects of CSNK1A1 on key biological pathways, such as the Wnt signaling pathway, where its aberration is often associated with cancer development. This makes these cell lines invaluable for both fundamental research and drug discovery, contextually aligning with current trends in personalized medicine and targeted therapies.
What sets CSNK1A1 Gene Knockout Cell Lines apart from conventional cell models is their ability to provide an authentic representation of the loss-of-function system in a controlled environment. Researchers can conduct experiments without the confounding effects of CSNK1A1 activity, enabling more accurate interpretations of experimental data. Moreover, these knockout models are versatile, compatible with various assay formats, including high-throughput screening, making them an efficient choice for laboratories pursuing groundbreaking discoveries.
In summary, CSNK1A1 Gene Knockout Cell Lines represent a cutting-edge resource for researchers and clinicians focused on understanding the multifaceted roles of kinases in health and disease. By harnessing the latest advancements in genetic engineering, our company is committed to providing high-quality biological tools that empower scientific innovation and progression in biomedical research.
Please note that all services are for research use only. Not intended for any clinical use.
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