Gene: CSGALNACT1
Official Full Name: chondroitin sulfate N-acetylgalactosaminyltransferase 1provided by HGNC
Gene Summary: This gene encodes an enzyme that transfers N-acetylglucosamine (GalNAc) to the core tetrasaccharide linker and to elongating chondroitin sulfate chains in proteoglycans. Knockout of the orthologous mouse gene indicates that the protein is necessary for normal cartilage development and aggrecan metabolism. Mutations in this gene are associated with multiple sclerosis progression, and with mild skeletal dysplasia and joint laxity. [provided by RefSeq, Aug 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18518 | CSGALNACT1 Knockout cell line (HeLa) | Human | CSGALNACT1 | 1:3~1:6 | Negative | Online Inquiry |
KO18519 | CSGALNACT1 Knockout cell line (HCT 116) | Human | CSGALNACT1 | 1:2~1:4 | Negative | Online Inquiry |
KO18520 | CSGALNACT1 Knockout cell line (A549) | Human | CSGALNACT1 | 1:3~1:4 | Negative | Online Inquiry |
CSGALNACT1 Gene Knockout Cell Lines are specifically engineered cellular models designed to study the function of the CSGALNACT1 gene, which encodes for the enzyme responsible for catalyzing the synthesis of carbohydrate moieties involved in glycoprotein and glycolipid biosynthesis. These knockout cell lines are generated using CRISPR-Cas9 technology, leading to precise deletions in the CSGALNACT1 gene, facilitating the investigation of its role in various biological processes.
The key mechanism of action is the removal of the CSGALNACT1 gene, allowing researchers to examine the subsequent phenotypic and biochemical changes that occur in cellular systems. By providing a platform to assess glycan structures and their functional implications, these knockout cell lines are invaluable in elucidating the pathways associated with glycosylation, which is critical for cell signaling, immune responses, and cellular communication.
Scientifically, CSGALNACT1 is implicated in various conditions, including cancer and developmental disorders, making these cell lines essential tools for both basic research and translational studies. Their applications extend beyond academia into pharmaceutical development, where they can assist in drug screening and therapeutic target validation.
One of the standout advantages of CSGALNACT1 Gene Knockout Cell Lines is their unparalleled specificity and reliability compared to alternative models such as siRNA or small molecule inhibitors, which often lack the precision and long-term applicability necessary for gene function studies. This specificity enhances the reproducibility of results, an essential factor for both researchers and clinicians involved in rigorous scientific inquiry.
In addition to offering robust research capabilities, our company prides itself on leveraging over a decade of expertise in gene editing and cell line development. Our commitment to providing high-quality, validated biological products ensures that your research can progress with confidence. CSGALNACT1 Gene Knockout Cell Lines represent a significant advancement in the study of glycosylation and its biological impacts, positioning your research at the cutting edge of molecular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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