Gene: CRYM
Official Full Name: crystallin muprovided by HGNC
Gene Summary: Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. [provided by RefSeq, Sep 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38406 | CRYM Knockout cell line (HCT 116) | Human | CRYM | 1:2~1:4 | Negative | Online Inquiry |
KO38407 | CRYM Knockout cell line (HEK293) | Human | CRYM | 1:3~1:6 | Negative | Online Inquiry |
KO38408 | CRYM Knockout cell line (A549) | Human | CRYM | 1:3~1:4 | Negative | Online Inquiry |
CRYM Gene Knockout Cell Lines are a transformative tool in genetic research, specifically designed to enable the study of the CRYM gene's function within cellular systems. This product features cell lines engineered to have a complete knockout of the CRYM gene, thereby facilitating an in-depth exploration of its physiological roles and contributions to various biological processes. By providing a robust model for gene function analysis, these cell lines allow researchers to investigate the implications of CRYM deficiency in areas such as metabolism, cell signaling, and disease pathology.
The key functionality of CRYM Gene Knockout Cell Lines revolves around their ability to eliminate the expression of the CRYM gene, which encodes for a mitochondrial enzyme involved in the metabolism of specific substrates. This knockout mechanism contrasts with traditional approaches that often retain residual gene activity, leading to confounding results. By utilizing CRYM knockout cells, researchers can more accurately characterize pathways and molecular interactions influenced by the absence of CRYM, thus enhancing the reliability and validity of experimental outcomes.
From a scientific perspective, these cell lines hold significant implications in both research and clinical settings. They serve as a model for studying metabolic disorders, neurodegenerative conditions, and cancer, where CRYM's involvement may play a critical role. Moreover, they offer a unique platform for drug discovery efforts aimed at modulating the pathways affected by CRYM activity.
What sets CRYM Gene Knockout Cell Lines apart from alternative models is their meticulous design and validation. Each cell line undergoes rigorous quality control to ensure a complete and consistent knockdown, providing users with highly reproducible experimental conditions. This specificity ensures that findings can be directly attributed to the absence of CRYM, eliminating ambiguities often associated with partial gene knockouts or knockdowns.
For researchers, clinicians, and biotechnology companies, the CRYM Gene Knockout Cell Lines represent a valuable resource, enabling cutting-edge investigations into gene function and disease mechanisms. Our commitment to advancing genetic research is reflected in our extensive expertise in developing high-quality biological products, underscoring our role as a trusted partner in the life sciences community. By integrating these cell lines into their research arsenal, professionals can unlock new insights that pave the way for innovative therapeutic approaches.
Please note that all services are for research use only. Not intended for any clinical use.
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