Gene: CRYL1
Official Full Name: crystallin lambda 1provided by HGNC
Gene Summary: The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene in the rabbit is thought to serve a structural role in the lens of the eye. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO23075 | CRYL1 Knockout cell line (HeLa) | Human | CRYL1 | 1:3~1:6 | Negative | Online Inquiry |
KO23076 | CRYL1 Knockout cell line (HCT 116) | Human | CRYL1 | 1:2~1:4 | Negative | Online Inquiry |
KO23077 | CRYL1 Knockout cell line (HEK293) | Human | CRYL1 | 1:3~1:6 | Negative | Online Inquiry |
KO23078 | CRYL1 Knockout cell line (A549) | Human | CRYL1 | 1:3~1:4 | Negative | Online Inquiry |
CRYL1 Gene Knockout Cell Lines are engineered cellular models that specifically lack the function of the CRYL1 gene, which encodes for the enzyme cysteine racemase. This critical enzyme plays an essential role in the synthesis of D-cysteine, an amino acid implicated in various neurotransmitter pathways. The CRYL1 Gene Knockout Cell Lines provide researchers with a powerful tool to study the physiological and pathological roles of D-cysteine and its involvement in neurobiology, metabolism, and potential therapeutic pathways.
The mechanism by which these cell lines function involves the targeted knockout of the CRYL1 gene using advanced genome editing technologies such as CRISPR-Cas9. By disrupting the normal expression of the CRYL1 protein, these models allow for the investigation of the functional consequences of the absence of D-cysteine on cellular activities. This is particularly valuable in understanding disorders linked to glutamatergic signaling and neurological conditions, enabling researchers to dissect the molecular mechanisms underlying such diseases more effectively.
In terms of scientific significance, CRYL1 Gene Knockout Cell Lines serve an important role in drug discovery and development, particularly in the context of neurodegenerative diseases where alterations in amino acid metabolism may contribute to pathogenesis. Furthermore, their use extends to cellular signaling research, metabolic profiling, and the potential identification of novel therapeutic targets.
What sets CRYL1 Gene Knockout Cell Lines apart from alternative models is their specificity and reliability; these cell lines have been meticulously validated, providing a consistent platform for reproducible results. The targeted nature of the knockout eliminates off-target effects, ensuring that findings are accurately attributed to the absence of the CRYL1 gene.
Ultimately, the value of CRYL1 Gene Knockout Cell Lines lies in their capacity to enhance our understanding of fundamental biological processes and pathological conditions. For researchers and clinicians pursuing innovative solutions in neuroscience and related fields, these cell lines represent an unparalleled resource. Our company, with its commitment to advancing biological research through high-quality model systems, is proud to offer this cutting-edge product, backed by years of expertise in genetic engineering and cellular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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