Gene: CREBL2
Official Full Name: cAMP responsive element binding protein like 2provided by HGNC
Gene Summary: cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38425 | CREBL2 Knockout cell line (HeLa) | Human | CREBL2 | 1:3~1:6 | Negative | Online Inquiry |
KO38426 | CREBL2 Knockout cell line (HCT 116) | Human | CREBL2 | 1:2~1:4 | Negative | Online Inquiry |
KO38427 | CREBL2 Knockout cell line (HEK293) | Human | CREBL2 | 1:3~1:6 | Negative | Online Inquiry |
KO38428 | CREBL2 Knockout cell line (A549) | Human | CREBL2 | 1:3~1:4 | Negative | Online Inquiry |
CREBL2 Gene Knockout Cell Lines are specifically engineered cellular models designed to investigate the functional role of the CREBL2 gene in various biological processes. This innovative product employs the CRISPR-Cas9 gene-editing technology to create precise knockouts, enabling researchers to analyze the gene's impact on cellular pathways, gene expression, and physiological functions. By removing or disabling the CREBL2 gene, these cell lines serve as vital tools for probing the pathways involved in cellular response mechanisms, metabolic regulation, and oncogenesis.
The key functionality of the CREBL2 Gene Knockout Cell Lines lies in their robustness for studying gene function through loss-of-function experiments. Researchers can effectively observe the phenotypic alterations, signaling cascades, and compensatory mechanisms that translate from CREBL2 deficiency. These insights are crucial for understanding the gene's role in various conditions, including inflammatory processes and cancer.
The scientific importance of this product is particularly evident in both research and clinical settings. In basic research, it aids in elucidating the fundamental biological roles of CREBL2, while its clinical application may extend to therapeutic avenues, including targeted gene therapies and drug development.
One of the distinct advantages of our CREBL2 Gene Knockout Cell Lines is their ease of use and reproducibility compared to alternative models that may not effectively mimic the in vivo conditions. Our cell lines are validated for consistent performance, providing a reliable platform for experiments that require high-quality biological materials.
Researchers and clinicians can greatly benefit from these cell lines, as they enable the exploration of complex biological questions with precision and clarity. Ultimately, choosing our CREBL2 Gene Knockout Cell Lines means investing in a product backed by thorough validation and an assurance of high-quality performance—crafted by a leading company in genetic engineering and cell model development. We pride ourselves on our commitment to advancing scientific discovery through our innovative biological products.
Please note that all services are for research use only. Not intended for any clinical use.
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