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CRACR2A Knockout Cell Lines

Gene: CRACR2A

Official Full Name: calcium release activated channel regulator 2Aprovided by HGNC

Gene Summary: Enables GTPase activity and calcium ion binding activity. Involved in several processes, including activation of store-operated calcium channel activity; positive regulation of JNK cascade; and store-operated calcium entry. Located in several cellular components, including Golgi apparatus; Weibel-Palade body; and immunological synapse. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05348 CRACR2A Knockout cell line (HCT 116) Human CRACR2A 1:2~1:4 Negative Online Inquiry
KO05349 CRACR2A Knockout cell line (HEK293) Human CRACR2A 1:3~1:6 Negative Online Inquiry
KO05350 CRACR2A Knockout cell line (A549) Human CRACR2A 1:3~1:4 Negative Online Inquiry

Background

CRACR2A Gene Knockout Cell Lines are advanced cellular models engineered to silence the CRACR2A gene, a critical player in calcium signaling and T cell activation. This gene encodes a protein that facilitates the dynamic assembly of signaling complexes crucial for various immune responses. By utilizing CRISPR-Cas9 technology, our knockout cell lines effectively eliminate the expression of CRACR2A, permitting researchers to investigate the physiological impacts of its absence on cellular behavior, signaling pathways, and gene expression profiles.

These cell lines serve multiple essential functions by enabling the study of calcium influx mechanisms and their downstream effects in immune cell activation and proliferation. By elucidating the role of the CRACR2A protein, researchers can better understand its implications in autoimmune diseases, cancer immunotherapy, and targeted drug responses. As a result, these knockout models are invaluable for advancing clinical and translational research.

What sets our CRACR2A Gene Knockout Cell Lines apart from conventional models is their validated specificity and ease of use. They are derived from well-characterized cellular backgrounds, ensuring consistent and reproducible results. Furthermore, our proprietary medium formulation promotes optimal growth and maintenance, which streamlines experimental workflows.

For researchers and clinicians focused on immunology and cellular signaling, these knockout cell lines provide unparalleled insights, aiding in the development of novel therapeutics and improving existing treatment modalities. Our company has a strong commitment to innovation in biological products, leveraging cutting-edge technologies to deliver high-quality cellular models that empower scientific discovery and enhance research outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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