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COX7C Knockout Cell Lines

Gene: COX7C

Official Full Name: cytochrome c oxidase subunit 7Cprovided by HGNC

Gene Summary: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38464 COX7C Knockout cell line (HeLa) Human COX7C 1:3~1:6 Negative Online Inquiry
KO38465 COX7C Knockout cell line (HCT 116) Human COX7C 1:2~1:4 Negative Online Inquiry
KO38466 COX7C Knockout cell line (HEK293) Human COX7C 1:3~1:6 Negative Online Inquiry

Background

COX7C Gene Knockout Cell Lines are a specialized series of genetically modified cell lines designed to study the functional impact of the COX7C gene, which encodes a critical subunit of the cytochrome c oxidase (CCO), a pivotal enzyme in the mitochondrial respiratory chain. By systematically disrupting the COX7C gene, these knockout cell lines enable researchers to investigate the gene's role in cellular respiration, energy metabolism, and various physiological processes.

The primary function of COX7C is to form a part of the electron transport chain, facilitating the transfer of electrons from cytochrome c to oxygen, ultimately promoting ATP synthesis within mitochondria. The knockout of COX7C leads to alterations in mitochondrial function, increased oxidative stress, and potential implications for diseases characterized by mitochondrial dysfunction, such as neurodegenerative disorders and metabolic syndromes. Through the use of these specialized cell lines, scientists can elucidate the cellular and molecular mechanisms underlying mitochondrial pathologies, offering new insights into disease mechanisms.

In research and clinical settings, COX7C Gene Knockout Cell Lines serve as invaluable tools for drug discovery, gene therapy, and understanding disease pathways linked to mitochondrial impairment. Their ability to model specific genetic variations provides researchers with an unparalleled opportunity to test therapeutic interventions or evaluate the biochemical consequences of inhibiting COX7C function.

Compared to alternative cell lines, our COX7C Gene Knockout Cell Lines are rigorously validated for specificity and efficiency in gene knockout, thus ensuring reliability in experimental results. The robust data derived from using these models not only accelerates research timelines but also enhances reproducibility, making them a preferred choice for leading laboratories.

For researchers and clinicians invested in mitochondrial research, the COX7C Gene Knockout Cell Lines represent a significant advancement that can enable groundbreaking discoveries that advance our understanding of metabolic diseases. Our company prides itself on delivering high-quality biological products backed by rigorous scientific research and expertise, empowering the scientific community to achieve meaningful breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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