Gene: COQ6
Official Full Name: coenzyme Q6, monooxygenaseprovided by HGNC
Gene Summary: The protein encoded by this gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. Knockdown of this gene in mouse and zebrafish results in decreased growth due to increased apoptosis. Mutations in this gene are associated with autosomal recessive coenzyme Q10 deficiency-6 (COQ10D6), which manifests as nephrotic syndrome with sensorineural deafness. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO23204 | COQ6 Knockout cell line (HeLa) | Human | COQ6 | 1:3~1:6 | Negative | Online Inquiry |
KO23205 | COQ6 Knockout cell line (HCT 116) | Human | COQ6 | 1:2~1:4 | Negative | Online Inquiry |
KO23206 | COQ6 Knockout cell line (HEK293) | Human | COQ6 | 1:3~1:6 | Negative | Online Inquiry |
KO23207 | COQ6 Knockout cell line (A549) | Human | COQ6 | 1:3~1:4 | Negative | Online Inquiry |
COQ6 Gene Knockout Cell Lines are meticulously engineered cellular models where the COQ6 gene has been inactivated, providing researchers with a vital tool for studying the implications of this gene in various biological processes. The COQ6 gene encodes for an enzyme critical in the coenzyme Q10 (CoQ10) biosynthetic pathway, which is central to mitochondrial function and energy production. By using these knockout cell lines, scientists can explore the role of COQ6 in cellular respiration, oxidative stress, and the pathophysiology of diseases characterized by mitochondrial dysfunction, such as cardiomyopathies and neurodegenerative disorders.
Functionally, the COQ6 knockout allows for the differentiation of cellular pathways influenced by CoQ10 availability, thereby enabling researchers to investigate mechanistic correlations between COQ6 activity and cellular health. This investigation is pivotal in understanding disease processes and developing therapeutic strategies targeting mitochondrial health.
From a scientific perspective, COQ6 Gene Knockout Cell Lines are invaluable in both research and clinical settings. They facilitate drug discovery targeting mitochondrial dysfunction and enhance our understanding of genetic contributions to disease. As models, they offer insights into metabolic disturbances and allow for the evaluation of potential interventions on mitochondrial bioenergetics.
Compared to traditional cell lines, which may retain the full functionality of the COQ6 gene, these knockout models provide a more authentic representation of cellular responses under pathological conditions, leading to more reliable experimental outcomes. Additionally, the specificity of gene knockout offers a level of precision that is unattainable through pharmacological inhibition or RNA interference.
Users, ranging from academic institutions to biotechnology firms, will find immense value in these cell lines due to their ability to provide clear, unambiguous data regarding the role of COQ6 in health and disease, leading to innovative research pathways and therapeutic solutions.
Our company, specialized in genetic engineering and cellular biology, prides itself on producing high-quality, reliable biological products. The COQ6 Gene Knockout Cell Lines exemplify our commitment to advancing scientific knowledge and supporting the research community's quest to unravel complex biological mechanisms.
Please note that all services are for research use only. Not intended for any clinical use.
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