Gene: COL15A1
Official Full Name: collagen type XV alpha 1 chainprovided by HGNC
Gene Summary: This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, May 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38480 | COL15A1 Knockout cell line (HeLa) | Human | COL15A1 | 1:3~1:6 | Negative | Online Inquiry |
COL15A1 Gene Knockout Cell Lines are specialized cellular models engineered for the specific deletion of the collagen type XV alpha 1 (COL15A1) gene. This gene encodes a protein crucial for the structural integrity of various tissues, particularly in the extracellular matrix. By knocking out COL15A1, these cell lines facilitate the study of its role in cellular processes such as adhesion, migration, and signaling, integral in both physiological and pathological contexts, including cancer metastasis and tissue repair mechanisms.
The primary function of COL15A1 Gene Knockout Cell Lines revolves around elucidating the contributions of this gene to human health and disease. These cell models enable researchers to investigate the functional consequences of COL15A1 loss on cellular morphology, behavior, and interaction with the extracellular environment. Mechanistically, the absence of COL15A1 can lead to alterations in collagens and other matrix proteins, affecting how cells behave and communicate within tissue architectures.
From a scientific perspective, these knockout cell lines are invaluable in both research and clinical applications. They provide insights into fibrotic diseases, muscular dystrophies, and other collagen-related disorders, facilitating the development of targeted therapies and diagnostic tools. Additionally, the application of these cell lines in drug discovery and regenerative medicine showcases their potential to revolutionize treatment strategies.
What sets COL15A1 Gene Knockout Cell Lines apart from alternative models is their specificity and precision in targeting the COL15A1 gene. This precision minimizes off-target effects, providing cleaner data and more reliable results than general knockdown strategies. Furthermore, they are provided with comprehensive validation and characterization data, ensuring that researchers can trust the consistency and reproducibility of their experiments.
For researchers, clinicians, and professionals in the field, investing in COL15A1 Gene Knockout Cell Lines represents a step forward in understanding complex biological systems and advancing therapeutic interventions. The unique characteristics of these cell lines allow users to drive innovation and discovery in ways that were previously unattainable.
Our company specializes in the development of high-quality biological products, ensuring that our offerings are backed by rigorous scientific research and expertise. By leveraging state-of-the-art techniques and a deep understanding of molecular biology, we provide researchers with the tools needed to make significant scientific advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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