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CNP Knockout Cell Lines

Gene: CNP

Official Full Name: 2'',3''-cyclic nucleotide 3'' phosphodiesteraseprovided by HGNC

Gene Summary: Predicted to enable 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Involved in substantia nigra development. Located in cytoplasm; extracellular space; and microtubule. Implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Biomarker of alcoholic liver cirrhosis; multiple sclerosis; and restless legs syndrome. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01765 CNP Knockout cell line (HeLa) Human CNP 1:3~1:6 Negative Online Inquiry
KO01766 CNP Knockout cell line (HCT 116) Human CNP 1:2~1:4 Negative Online Inquiry
KO01767 CNP Knockout cell line (HEK293) Human CNP 1:3~1:6 Negative Online Inquiry
KO01768 CNP Knockout cell line (A549) Human CNP 1:3~1:4 Negative Online Inquiry

Background

CNP Gene Knockout Cell Lines are specifically engineered cellular models characterized by the targeted disruption of the CNP (Cyclic nucleotide phosphodiesterase) gene, allowing researchers to investigate the biological functions and pathways influenced by this important signaling molecule. These cell lines provide a vital resource for elucidating the role of CNP in various physiological and pathological processes, including cell proliferation, differentiation, and response to external stimuli.

The primary mechanism of action involves the inactivation of the CNP gene using CRISPR-Cas9 technology, which results in a knockout effect that leads to a dearth of CNP protein expression. This alteration enables researchers to study the specific outcomes and biochemical pathways affected by the absence of CNP, providing insights into its contributions to cellular signaling and development. The ability to assess changes in gene expression, metabolic activity, and cellular behavior in these knockout cells creates a potent platform for functional genomics studies.

In terms of scientific significance, CNP Gene Knockout Cell Lines provide invaluable tools in both research and clinical settings, contributing to areas such as drug discovery, disease modeling, and therapeutic development. These models facilitate a deeper understanding of CNP's role in various diseases, including cancer and cardiovascular disorders, thus hastening the pace of clinical advancements.

Compared to traditional cell lines, CNP Gene Knockout Cell Lines offer unparalleled specificity and control, reducing background noise and enabling clearer data interpretation. This specificity allows for more robust experimental designs and a higher likelihood of obtaining translatable results. Furthermore, these cell lines can be coupled with various assays, including high-throughput screening and functional assays, making them versatile across platforms.

For researchers and clinicians focusing on molecular biology, genomics, or therapeutic interventions, the CNP Gene Knockout Cell Lines are an essential addition to experimental design, providing a reliable way to investigate the nuances of signal transduction pathways. By leveraging our extensive experience in developing advanced biological products, we ensure that our CNP Gene Knockout Cell Lines come with high-quality assurance and comprehensive support, empowering users to maximize their research potential.

Please note that all services are for research use only. Not intended for any clinical use.

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