Gene: CNOT9
Official Full Name: CCR4-NOT transcription complex subunit 9provided by HGNC
Gene Summary: This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05379 | CNOT9 Knockout cell line (HeLa) | Human | CNOT9 | 1:3~1:6 | Negative | Online Inquiry |
KO05380 | CNOT9 Knockout cell line (HCT 116) | Human | CNOT9 | 1:2~1:4 | Negative | Online Inquiry |
KO05381 | CNOT9 Knockout cell line (HEK293) | Human | CNOT9 | 1:3~1:6 | Negative | Online Inquiry |
KO05382 | CNOT9 Knockout cell line (A549) | Human | CNOT9 | 1:3~1:4 | Negative | Online Inquiry |
CNOT9 Gene Knockout Cell Lines are specifically engineered cellular models developed for the precise study of CNOT9 gene functions and mechanisms in various biological contexts. These cell lines are created by utilizing CRISPR-Cas9 gene-editing technology to selectively disrupt the CNOT9 gene, resulting in a cellular environment devoid of its functional contributions. As a key member of the CCR4-NOT complex, CNOT9 plays an integral role in RNA regulation, influencing various processes including mRNA degradation, gene expression control, and overall cellular homeostasis.
The primary function of CNOT9 is its involvement in transcriptional regulation and post-transcriptional modifications, making it essential for understanding gene regulation pathways. By utilizing these knockout cell lines, researchers can investigate the downstream effects of CNOT9 absence, elucidating its role in cellular processes such as proliferation, differentiation, and response to stress. Furthermore, these models are pivotal in cancer research, given the link between misregulated RNA processes and tumor progression.
One of the distinguishing advantages of CNOT9 Gene Knockout Cell Lines is their specificity and reliability compared to other methods such as RNA interference, which can have off-target effects. The precise genome editing ensures that researchers are studying the consequences of targeted gene loss without the confounding variables inherent in traditional methods. Additionally, these cell lines can be utilized in various applications, including drug screening, functional genomics, and the exploration of disease mechanisms, thereby providing a versatile tool for both basic and applied research.
For researchers and clinicians, the availability of CNOT9 Gene Knockout Cell Lines offers a unique opportunity to investigate gene function in a controlled environment, accelerating discoveries in gene regulation and diseases associated with CNOT9 dysregulation. Our company, with extensive experience in cellular technology and gene modification, is committed to providing high-quality, precisely engineered biological products that are integral to advancing research and therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
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