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CNNM2 Knockout Cell Lines

Gene: CNNM2

Official Full Name: cyclin and CBS domain divalent metal cation transport mediator 2provided by HGNC

Gene Summary: This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20818 CNNM2 Knockout cell line (HeLa) Human CNNM2 1:3~1:6 Negative Online Inquiry
KO20819 CNNM2 Knockout cell line (HCT 116) Human CNNM2 1:2~1:4 Negative Online Inquiry
KO20820 CNNM2 Knockout cell line (HEK293) Human CNNM2 1:3~1:6 Negative Online Inquiry
KO20821 CNNM2 Knockout cell line (A549) Human CNNM2 1:3~1:4 Negative Online Inquiry

Background

CNNM2 Gene Knockout Cell Lines represent a state-of-the-art tool for exploring the function of the CNNM2 gene, which is implicated in crucial processes such as magnesium ion transport and cellular homeostasis. These genetically modified cell lines are designed to facilitate the study of CNNM2’s role in various biological pathways, contributing to our understanding of its implications in diseases associated with magnesium imbalance, such as cardiovascular disorders and neurodegenerative diseases.

The primary function of CNNM2 gene knockout cell lines is to create a cellular environment devoid of the CNNM2 gene expression. This allows researchers to observe phenotypic changes and biochemical pathways that may be altered in the absence of CNNM2, facilitating a deeper exploration of its biological mechanisms. By utilizing advanced genome-editing techniques, such as CRISPR/Cas9, these cell lines ensure precise and reliable knockout of the gene, supporting high reproducibility in experimental results.

From a scientific and clinical perspective, the applications of CNNM2 gene knockout cell lines are vast. They are particularly valuable in pharmacological studies aimed at discovering new therapeutic strategies for conditions linked with magnesium dysregulation. Additionally, these cell lines can serve as models for understanding the basic biology of magnesium transport and the consequent cellular implications, thus providing insights that could lead to innovative treatments.

Compared to standard cell lines, the CNNM2 gene knockout cell lines offer unique advantages, including specific gene targeting capabilities and the potential for high throughput screening of drugs or compounds that interact with pathways influenced by CNNM2. These properties make them indispensable for researchers focused on translational medicine, aiming to bridge basic research with clinical applications.

For researchers and clinicians, the value of CNNM2 gene knockout cell lines lies in their ability to unravel complex biological interactions, paving the way for novel clinical interventions. Utilizing these cell lines can significantly enhance research outcomes, streamline the investigation into magnesium-related pathologies, and ultimately contribute to advancements in personalized medicine.

At our company, we pride ourselves on our expertise in producing high-quality biological products. Our commitment to innovation and precision in gene editing has enabled us to deliver superior cell line models tailored to the specific needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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