Gene: CNIH2
Official Full Name: cornichon family AMPA receptor auxiliary protein 2provided by HGNC
Gene Summary: The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21168 | CNIH2 Knockout cell line (HEK293) | Human | CNIH2 | 1:3~1:6 | Negative | Online Inquiry |
KO21169 | CNIH2 Knockout cell line (A549) | Human | CNIH2 | 1:3~1:4 | Negative | Online Inquiry |
CNIH2 Gene Knockout Cell Lines are specialized cellular models that have undergone targeted gene deletion of the CNIH2 gene, which encodes for the alpha-1 subunit of a key ion channel involved in neurotransmitter release and synaptic transmission. By utilizing CRISPR-Cas9 genome editing technology, these cell lines provide a powerful tool for researchers to investigate the physiological and pathological roles of the CNIH2 gene in various biological processes.
The CNIH2 knockout mechanism results in the precise removal of functionality associated with the CNIH2 protein, thereby enabling researchers to study alterations in ionic currents, synaptic efficacy, and receptor interactions. This insight is crucial in understanding how dysregulation of synaptic transmission can contribute to neurological disorders, such as epilepsy, schizophrenia, and other mental health conditions. Furthermore, these cell lines facilitate drug screening and toxicology studies by allowing for the assessment of how therapeutic interventions might restore normal function or ameliorate disease phenotypes.
What sets CNIH2 Gene Knockout Cell Lines apart is their robust reliability and ease of use in both in vitro and in vivo studies. Unlike traditional methods that are often time-consuming and less precise, our knockout lines provide immediate access to a genetic model that can significantly accelerate research timelines. Moreover, these cell lines are validated for consistent performance, ensuring that researchers can depend on their results.
The value of CNIH2 Gene Knockout Cell Lines extends beyond their role in basic research; they are essential assets in preclinical studies aimed at identifying novel therapeutics for synaptic-related disorders. By streamlining the research process, these knockout lines allow scientists to focus on discovery, ultimately leading to innovative approaches in treating complex neurobiological conditions.
At [Your Company Name], we leverage extensive expertise in genetic engineering and cell line development to provide high-quality research products like the CNIH2 Gene Knockout Cell Lines. Our commitment to scientific advancement ensures that researchers and clinicians have access to reliable tools that enhance their ability to translate findings into meaningful applications.
Please note that all services are for research use only. Not intended for any clinical use.
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