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CMTM7 Knockout Cell Lines

Gene: CMTM7

Official Full Name: CKLF like MARVEL transmembrane domain containing 7provided by HGNC

Gene Summary: This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30922 CMTM7 Knockout cell line (HeLa) Human CMTM7 1:3~1:6 Negative Online Inquiry
KO30923 CMTM7 Knockout cell line (HCT 116) Human CMTM7 1:2~1:4 Negative Online Inquiry
KO30924 CMTM7 Knockout cell line (HEK293) Human CMTM7 1:3~1:6 Negative Online Inquiry
KO30925 CMTM7 Knockout cell line (A549) Human CMTM7 1:3~1:4 Negative Online Inquiry

Background

CMTM7 Gene Knockout Cell Lines represent a pivotal advancement in cellular biology research, designed to facilitate in-depth studies of the CMTM7 gene's function and its role in various biological processes. These cell lines have been engineered using CRISPR/Cas9 technology to edit the genomic sequence of the CMTM7 gene, resulting in the complete ablation of its expression. This knockout model allows researchers to investigate the gene's contribution to cellular signaling pathways, proliferation, differentiation, and potential implications in disease mechanisms, particularly in cancer and neurological disorders.

The primary mechanism by which the CMTM7 Gene Knockout Cell Lines operate involves the interruption of the normal gene function due to the targeted deletion of the CMTM7 gene sequence. The absence of CMTM7 protein enables researchers to perform comparative studies between wild-type and knockout cells, elucidating the downstream effects of the gene's loss and acquiring insights into compensatory pathways that may be activated in its absence.

The scientific importance of these cell lines is underscored by their applications in both basic research and translational studies, allowing for the exploration of gene function in cellular contexts that resemble physiological conditions. Their utilization in drug discovery, biomarker identification, and preclinical testing can lead to novel therapeutic strategies and interventions.

What distinguishes CMTM7 Gene Knockout Cell Lines from alternative models is their high specificity, reliability, and the ability to reproduce physiological conditions inherent to human cells. These cell lines are rigorously characterized, assuring researchers of their integrity and reproducibility. Moreover, these knockout models can significantly reduce experimental complexity and save valuable time in the research workflow by providing a clear experimental framework.

For researchers and clinicians pursuing cutting-edge studies, CMTM7 Gene Knockout Cell Lines offer an invaluable tool to enhance understanding of gene function and to translate these insights into clinical applications. At [Your Company Name], we are committed to providing high-quality biological products and innovative solutions, backed by our expertise in genetic engineering and cellular biology, ensuring our customers have access to advanced tools that propel their research forward.

Please note that all services are for research use only. Not intended for any clinical use.

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