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CLOCK Knockout Cell Lines

Gene: CLOCK

Official Full Name: clock circadian regulatorprovided by HGNC

Gene Summary: The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09702 CLOCK Knockout cell line (HeLa) Human CLOCK 1:3~1:6 Negative Online Inquiry
KO09703 CLOCK Knockout cell line (HCT 116) Human CLOCK 1:2~1:4 Negative Online Inquiry
KO09704 CLOCK Knockout cell line (HEK293) Human CLOCK 1:3~1:6 Negative Online Inquiry
KO09705 CLOCK Knockout cell line (A549) Human CLOCK 1:3~1:4 Negative Online Inquiry

Background

CLOCK Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the CLOCK gene, a critical component in the regulation of circadian rhythms. These cell lines serve as vital tools for researchers investigating the mechanisms and biological effects of circadian clock genes in a variety of contexts. By effectively silencing the CLOCK gene, the cell lines allow for the elucidation of its role in cellular processes, metabolism, and gene expression patterns associated with biological rhythms.

The primary function of CLOCK gene knockout cell lines is to facilitate studies on circadian rhythm disruptions and their implications in human health, including sleep disorders, metabolic syndromes, and other chronobiology-related conditions. The absence of CLOCK expression enables scientists to observe comparative changes in metabolic pathways, hormone regulation, and the overall physiology of the cells, contributing to a deeper understanding of how daily cycles influence cellular behavior.

In terms of scientific importance, these cell lines are invaluable in both research and clinical applications, paving the way for the development of novel therapeutic strategies targeting circadian rhythms. They serve as platforms for drug discovery, allowing the testing of compounds that may modulate circadian disruptions or counteract the adverse effects of circadian misalignment on health.

What sets CLOCK Gene Knockout Cell Lines apart from alternative models is their specificity and precision in studying the direct effects of CLOCK gene deletion. Unlike some competing models that may introduce off-target effects, these precisely engineered cell lines provide a more accurate representation of genetic loss of function. This specificity leads to more reliable data and reproducible outcomes, a critical factor in advancing circadian biology research.

For researchers and clinicians alike, CLOCK Gene Knockout Cell Lines represent an essential resource that enhances the capability to dissect complex biological processes governed by circadian rhythms. Their use can lead to innovative insights into various health issues, driving forward the frontiers of chronotherapy and metabolic research.

Our company is committed to providing advanced biological research tools, exemplified by our rigorously developed CLOCK Gene Knockout Cell Lines, which are backed by expertise in genetic engineering and a dedication to supporting scientific innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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