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CLK2 Knockout Cell Lines

Gene: CLK2

Official Full Name: CDC like kinase 2provided by HGNC

Gene Summary: This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05697 CLK2 Knockout cell line (HeLa) Human CLK2 1:3~1:6 Negative Online Inquiry
KO05698 CLK2 Knockout cell line (HCT 116) Human CLK2 1:2~1:4 Negative Online Inquiry
KO05699 CLK2 Knockout cell line (HEK293) Human CLK2 1:3~1:6 Negative Online Inquiry
KO05700 CLK2 Knockout cell line (A549) Human CLK2 1:3~1:4 Negative Online Inquiry

Background

CLK2 Gene Knockout Cell Lines are a sophisticated biological tool designed to facilitate the study of CLK2 (Clock Gene 2) function through precise gene-editing. These cell lines have undergone targeted gene knockout, which results in the complete inactivation of the CLK2 gene, allowing researchers to investigate the downstream effects of its deletion in various cellular contexts.

The key mechanism behind CLK2 Gene Knockout Cell Lines lies in the CRISPR/Cas9 gene-editing technology, which enables the specific disruption of the CLK2 gene. By deactivating this gene, researchers can explore its role in critical biological processes such as circadian rhythms, cell proliferation, and response to stresses. The resultant cell lines serve as valuable models for discerning the contributions of CLK2 to cellular signaling pathways and metabolic regulation, making them highly relevant in fields like chronobiology and cancer research.

Scientifically, CLK2 Gene Knockout Cell Lines hold tremendous importance for both research and clinical applications. They provide a unique platform for examining how cellular functions are altered in the absence of CLK2, which may uncover novel therapeutic targets for diseases linked to circadian disruptions. In clinical settings, understanding CLK2's role may pave the way for innovative treatments and management strategies for associated disorders.

Compared to traditional gene knockout methods, our cell lines are defined by their ease of use and reproducibility, ensuring consistent performance across various experiments. Additionally, they come with thorough characterization data, ensuring researchers can trust in the reliability of their findings.

For researchers, clinicians, and pharmaceutical developers, CLK2 Gene Knockout Cell Lines epitomize a powerful resource that enhances the capacity to investigate complex biological systems. Our company prides itself on providing high-quality products backed by extensive research expertise, ensuring that our offerings not only meet but exceed the scientific community’s demands for innovative and reliable biological research tools.

Please note that all services are for research use only. Not intended for any clinical use.

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