Gene: CLIC1
Official Full Name: chloride intracellular channel 1provided by HGNC
Gene Summary: Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04752 | CLIC1 Knockout cell line (HeLa) | Human | CLIC1 | 1:3~1:6 | Negative | Online Inquiry |
KO04753 | CLIC1 Knockout cell line (HCT 116) | Human | CLIC1 | 1:2~1:4 | Negative | Online Inquiry |
KO04754 | CLIC1 Knockout cell line (HEK293) | Human | CLIC1 | 1:3~1:6 | Negative | Online Inquiry |
KO04755 | CLIC1 Knockout cell line (A549) | Human | CLIC1 | 1:3~1:4 | Negative | Online Inquiry |
CLIC1 Gene Knockout Cell Lines are engineered cellular models specifically designed to facilitate the study of chloride intracellular channel 1 (CLIC1) gene functions and their implications in cellular physiology and pathophysiology. These cell lines have been meticulously created using CRISPR/Cas9 technology to induce precise gene deletions, enabling researchers to investigate the role of CLIC1 in various biological processes, including ion transport, cell proliferation, and apoptosis.
The key mechanism of action for these knockout cell lines lies in their ability to eliminate CLIC1 expression, offering a clear platform for analyzing both the molecular dynamics and physiological consequences arising from the absence of this critical ion channel. Researchers can utilize these cell lines to explore the involvement of CLIC1 in disease states such as cancer, neurological disorders, and cardiovascular diseases, thereby advancing our understanding of its biological significance.
The scientific importance of CLIC1 Gene Knockout Cell Lines extends into both fundamental research and clinical applications. In research settings, they serve as vital tools for drug discovery, biomarker identification, and therapeutic target validation. Clinically, these cell lines can assist in the development of targeted therapies, providing a basis for personalized medicine strategies aimed at diseases involving dysregulated chloride ion transport.
Compared to existing alternatives, CLIC1 Gene Knockout Cell Lines stand out due to their specificity and precision in mimicking CLIC1-deficient conditions. While traditional methods, such as pharmacological inhibition or RNA interference, can offer temporary results, our knockout cell lines provide a stable and repeatable system for long-term studies, enhancing research reliability.
For researchers and clinicians alike, the CLIC1 Gene Knockout Cell Lines represent a valuable resource, enabling deeper insights into CLIC1 biology and its broader implications in health and disease. Our company, with extensive expertise in genetic engineering and cellular biology, is committed to providing high-quality biological tools that empower the scientific community to make significant advancements in understanding complex biological phenomena and improving therapeutic strategies.
Please note that all services are for research use only. Not intended for any clinical use.
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