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CLDN4 Knockout Cell Lines

Gene: CLDN4

Official Full Name: claudin 4provided by HGNC

Gene Summary: The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38453 CLDN4 Knockout cell line (HeLa) Human CLDN4 1:3~1:6 Negative Online Inquiry
KO38454 CLDN4 Knockout cell line (HCT 116) Human CLDN4 1:2~1:4 Negative Online Inquiry
KO38455 CLDN4 Knockout cell line (A549) Human CLDN4 1:3~1:4 Negative Online Inquiry

Background

CLDN4 Gene Knockout Cell Lines are specialized cellular models created through targeted gene editing techniques, specifically designed to inactivate the CLDN4 gene, a critical component of tight junctions in epithelial cells. These cell lines serve as invaluable tools for researchers aiming to study the role of CLDN4 in various biological processes, including cellular permeability, tissue integrity, and cancer progression.

The primary function of these knockout cell lines lies in their ability to facilitate the investigation of the biological effects of CLDN4 absence. By utilizing techniques like CRISPR-Cas9, these cell lines enable researchers to observe alterations in cellular behavior, signaling pathways, and responses to external stimuli. This mechanistic understanding is essential for elucidating the gene's implications in both normal physiology and pathological conditions, particularly in relation to diseases such as cancer where tight junction integrity is often disrupted.

The scientific importance of CLDN4 Gene Knockout Cell Lines extends beyond basic research, as they hold significant applications in drug development and therapeutic interventions. Understanding the interactions of CLDN4 with other molecular players can lead to novel insights into disease mechanisms and potential therapeutic targets, particularly in tumor biology, where its expression is frequently deregulated.

One of the key advantages of our CLDN4 Gene Knockout Cell Lines is their precision and reproducibility. Unlike conventional models, which may exhibit heterogeneous genetic backgrounds, these knockout lines provide consistent and reliable results, allowing researchers to derive clearer conclusions. Moreover, our cell lines undergo rigorous quality control to ensure high viability and functional integrity, making them a robust choice for any laboratory setting.

Investing in CLDN4 Gene Knockout Cell Lines is invaluable for researchers and clinicians alike, as they not only enhance our understanding of complex biological systems but also pave the way for innovative therapeutic strategies. At [Your Company Name], we are committed to advancing biological research and providing high-quality products tailored to meet the needs of the scientific community, supported by our extensive expertise in gene editing technologies and cell line development.

Please note that all services are for research use only. Not intended for any clinical use.

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