Gene: CKAP2L
Official Full Name: cytoskeleton associated protein 2 likeprovided by HGNC
Gene Summary: The protein encoded by this gene is thought to be a mitotic spindle protein important to neural stem or progenitor cells. Mutations in this gene have been associated with spindle organization defects, including mitotic spindle defects, lagging chromosomes, and chromatin bridges. There is evidence that mutations in this gene are associated with Filippi syndrome, characterized by growth defects, microcephaly, intellectual disability, facial feature defects, and syndactyly. There is a pseudogene of this gene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22050 | CKAP2L Knockout cell line (HeLa) | Human | CKAP2L | 1:3~1:6 | Negative | Online Inquiry |
KO22051 | CKAP2L Knockout cell line (HCT 116) | Human | CKAP2L | 1:2~1:4 | Negative | Online Inquiry |
KO22052 | CKAP2L Knockout cell line (HEK293) | Human | CKAP2L | 1:3~1:6 | Negative | Online Inquiry |
KO22053 | CKAP2L Knockout cell line (A549) | Human | CKAP2L | 1:3~1:4 | Negative | Online Inquiry |
CKAP2L Gene Knockout Cell Lines represent a cutting-edge biological tool designed for researchers seeking to elucidate the functional role of the CKAP2L gene in cellular processes. These cell lines have been meticulously engineered to disrupt the CKAP2L gene through CRISPR-Cas9 technology, resulting in a complete loss of gene expression, which enables the study of its downstream effects and interactions within various biological contexts.
The primary function of these knockout cell lines lies in their ability to provide a clear model for investigating the consequences of CKAP2L gene ablation on cell biology. CKAP2L, known for its involvement in cell cycle regulation, cytoskeleton organization, and cellular response to stress, makes these cell lines particularly valuable for understanding disease mechanisms, including cancer proliferation and response to therapy. By employing these cell lines, researchers can uncover the specific pathways and processes influenced by CKAP2L, leading to potential new targets for intervention in disease states.
The scientific significance of CKAP2L Gene Knockout Cell Lines extends to multiple applications in both research and clinical settings. These include drug discovery, functional genomics, and the development of personalized medicine approaches. The ability to study gene function in a controlled manner allows for more accurate modeling of human diseases, providing a critical assay platform for the evaluation of therapeutic strategies.
What sets CKAP2L Gene Knockout Cell Lines apart from existing alternatives is the precision of the gene editing technology used, combined with the extensive characterization of these cell lines to ensure robustness and reproducibility. Researchers can thereby trust the reliability of experimental outcomes, making these cell lines indispensable for high-quality investigations.
In conclusion, CKAP2L Gene Knockout Cell Lines offer a promising avenue for advancing our understanding of gene function and its implications in human diseases. With our company’s expertise in genomic engineering and commitment to high-quality biological reagents, we provide researchers and clinicians with tools that not only facilitate groundbreaking discoveries but also drive forward the realms of therapeutic development and molecular biology research.
Please note that all services are for research use only. Not intended for any clinical use.
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