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CITED4 Knockout Cell Lines

Gene: CITED4

Official Full Name: Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4provided by HGNC

Gene Summary: The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18680 CITED4 Knockout cell line (HeLa) Human CITED4 1:3~1:6 Negative Online Inquiry
KO18681 CITED4 Knockout cell line (A549) Human CITED4 1:3~1:4 Negative Online Inquiry

Background

CITED4 Gene Knockout Cell Lines are specialized cellular models designed to investigate the functional roles of the CITED4 gene, which is implicated in various biological processes, including cellular proliferation, differentiation, and angiogenesis. These engineered cell lines have undergone targeted gene disruption, resulting in the complete knockout of CITED4, thereby allowing researchers to assess the gene's contribution to specific pathways and cellular responses.

The primary mechanism by which CITED4 Gene Knockout Cell Lines operate is through the elimination of CITED4 expression, enabling the study of altered gene interactions and signaling cascade activities that are typically mediated by this gene. By utilizing these knockout models, researchers can gain insights into the pathophysiological mechanisms of diseases, particularly those related to cancer and developmental disorders. This makes them invaluable tools in both preclinical and translational research settings.

Their scientific importance extends to diverse applications, ranging from elucidating gene function in development and disease to testing therapeutic interventions. The use of CITED4-deficient cell lines facilitates a more accurate understanding of biological processes and experimental outcomes, enhancing the validity of scientific data generated in vitro.

A distinct advantage of the CITED4 Gene Knockout Cell Lines lies in their specificity and reliability, surpassing traditional methods such as siRNA or chemical inhibitors that can generate off-target effects. Additionally, these stable knockout models offer consistent performance over time, which is essential for longitudinal studies or experimental replication.

For researchers and clinicians focused on unraveling the complexities of gene function in diverse biological contexts, these cell lines represent a cutting-edge solution. They serve not only as a platform for basic research but also as a stepping stone towards developing targeted therapies.

In summary, our company specializes in producing high-quality gene knockout models, underpinned by a commitment to advancing scientific understanding. We leverage our expertise in gene editing technologies to provide innovative tools that empower researchers and support breakthroughs in biomedical science.

Please note that all services are for research use only. Not intended for any clinical use.

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