Gene: CHTOP
Official Full Name: chromatin target of PRMT1provided by HGNC
Gene Summary: This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28345 | CHTOP Knockout cell line (HeLa) | Human | CHTOP | 1:3~1:6 | Negative | Online Inquiry |
KO28346 | CHTOP Knockout cell line (HCT 116) | Human | CHTOP | 1:2~1:4 | Negative | Online Inquiry |
KO28347 | CHTOP Knockout cell line (HEK293) | Human | CHTOP | 1:3~1:6 | Negative | Online Inquiry |
KO28348 | CHTOP Knockout cell line (A549) | Human | CHTOP | 1:3~1:4 | Negative | Online Inquiry |
CHTOP Gene Knockout Cell Lines are genetically engineered cell lines specifically designed for the functional study of the CHTOP gene (C-terminal Helix-Loop-Helix Protein). These cell lines are created through CRISPR-Cas9 gene-editing technology, effectively knocking out the CHTOP gene to assess its role in various cellular processes, including RNA metabolism, transcription regulation, and responses to stress. By removing this specific gene, researchers can gain insights into how its absence affects cellular function and contributes to pathophysiological conditions.
The primary mechanism behind CHTOP Gene Knockout Cell Lines involves the precise deletion of exon sequences, achieved through targeted delivery of CRISPR components. This process allows for the elucidation of CHTOP's contribution to cellular mechanisms at a molecular level, providing a robust platform for functional assays. The ability to study gene function in a controlled environment fosters a better understanding of fundamental biological processes and enhances the potential for discovering therapeutic targets in diseases where CHTOP plays a crucial role.
Scientifically, these knockout cell lines hold significant value, especially in research and clinical settings that investigate genetic disorders, cancer biology, and metabolic syndromes. They facilitate high-throughput screening for drug development and enable researchers to identify potential biomarkers associated with disease progression. Compared to alternative models, such as wild-type cell lines or less precise knockout systems, CHTOP Gene Knockout Cell Lines offer greater specificity, reproducibility, and a clear understanding of gene function.
Moreover, the unique selling points of CHTOP Gene Knockout Cell Lines include their customizable nature, enabling the development of specific lines tailored to particular research needs. This flexibility allows researchers to create experimental conditions that closely mimic physiological states, making the findings more applicable to real-world scenarios.
In conclusion, the CHTOP Gene Knockout Cell Lines represent a pivotal resource for researchers and clinicians seeking to unravel the complexities of gene function. Our company specializes in state-of-the-art gene editing technologies, ensuring that our product offerings provide unparalleled quality and reliability in biological research. By delivering these advanced tools, we empower scientists to drive innovative discoveries in the genomics field.
Please note that all services are for research use only. Not intended for any clinical use.
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