Gene: CHN1
Official Full Name: chimerin 1provided by HGNC
Gene Summary: This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38558 | CHN1 Knockout cell line (HeLa) | Human | CHN1 | 1:3~1:6 | Negative | Online Inquiry |
KO38559 | CHN1 Knockout cell line (HCT 116) | Human | CHN1 | 1:2~1:4 | Negative | Online Inquiry |
KO38560 | CHN1 Knockout cell line (HEK293) | Human | CHN1 | 1:3~1:6 | Negative | Online Inquiry |
KO38561 | CHN1 Knockout cell line (A549) | Human | CHN1 | 1:3~1:4 | Negative | Online Inquiry |
CHN1 Gene Knockout Cell Lines are genetically engineered cellular models designed specifically for the targeted disruption of the CHN1 gene, which encodes for a vital protein involved in multiple cellular processes, including neurotransmitter transportation and metabolic regulation. Through precise CRISPR-Cas9 gene editing technology, these cell lines facilitate the study of CHN1’s role in various physiological and pathological contexts.
The key function of CHN1 Gene Knockout Cell Lines lies in their ability to provide insights into the molecular and cellular consequences resulting from the absence of the CHN1 protein. This is particularly useful in investigating mechanisms underlying neurodevelopmental disorders, metabolic diseases, and certain types of cancer. By studying these knockout lines, researchers can elucidate pathways associated with CHN1, assess the impact of its loss on cellular behavior, and identify potential therapeutic targets.
The scientific importance of CHN1 Gene Knockout Cell Lines extends into both research and clinical settings. They serve as invaluable tools for drug discovery, biomarker identification, and functional studies aimed at understanding disease mechanisms. Additionally, they can assist in preclinical assessments of therapeutic strategies aimed at restoring normal function or compensating for the loss of CHN1.
What sets CHN1 Gene Knockout Cell Lines apart from traditional cellular models is the precision of gene editing, leading to a complete and reproducible knockout that allows for clearer interpretation of results. Unlike transient knockdown techniques that may yield variable outcomes, these stable cell lines ensure consistent expression profiles, thus enhancing the reliability of research findings.
For researchers and clinicians, the value of CHN1 Gene Knockout Cell Lines lies in their potential to accelerate the discovery of novel insights into disease pathology and therapeutic interventions, ultimately contributing to improved patient outcomes. Our company's expertise in genetic engineering and commitment to quality ensures that these cell lines are rigorously validated and ready for immediate application in diverse scientific inquiries.
Please note that all services are for research use only. Not intended for any clinical use.
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