Gene: CHMP4C
Official Full Name: charged multivesicular body protein 4Cprovided by HGNC
Gene Summary: CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02792 | CHMP4C Knockout cell line (HeLa) | Human | CHMP4C | 1:3~1:6 | Negative | Online Inquiry |
KO02793 | CHMP4C Knockout cell line (HCT 116) | Human | CHMP4C | 1:2~1:4 | Negative | Online Inquiry |
KO02794 | CHMP4C Knockout cell line (HEK293) | Human | CHMP4C | 1:3~1:6 | Negative | Online Inquiry |
KO02795 | CHMP4C Knockout cell line (A549) | Human | CHMP4C | 1:3~1:4 | Negative | Online Inquiry |
CHMP4C Gene Knockout Cell Lines are advanced cellular models engineered to lack the CHMP4C gene, which plays a critical role in the endosomal sorting complex required for transport (ESCRT) machinery. This gene is pivotal for properly regulating cellular processes such as membrane budding, cytokinesis, and the repair of damaged membranes. By utilizing these knockout cell lines, researchers can investigate the specific functions and signaling pathways influenced by CHMP4C, including its impact on apoptosis and viral budding mechanisms.
The key functionality of these cell lines is rooted in the precise gene editing technology that facilitates the selective inactivation of the CHMP4C gene. As a result, researchers can create controlled environments to elucidate the cellular consequences of CHMP4C depletion, enabling them to uncover intricate biological processes and disease mechanisms. This is especially relevant in studies concerning cancer, neurodegeneration, and infectious diseases, where alterations in membrane dynamics can significantly contribute to pathogenesis.
The scientific importance of CHMP4C Gene Knockout Cell Lines extends into both research and clinical settings, where they serve as invaluable tools for drug development and biomarker discovery. Their unique ability to model specific cellular responses to therapeutic interventions allows clinicians to predict treatment outcomes with greater accuracy. Additionally, these cell lines can be employed in high-throughput screening assays to identify potential drug candidates targeting pathways influenced by CHMP4C.
One of the primary advantages of utilizing these knockout cell lines compared to traditional wild-type cell lines is their ability to provide clearer insights into gene function without the confounding effects of compensatory mechanisms. This specificity enhances the reliability of experimental results, making it easier for researchers to draw conclusions about the roles of the CHMP4C gene in various biological contexts.
For researchers and clinicians aiming to dissect complex cellular interactions or develop novel therapeutic strategies, CHMP4C Gene Knockout Cell Lines offer a distinct advantage. They empower users to conduct targeted research with enhanced precision, ultimately accelerating discoveries that can lead to impactful medical innovations.
With a commitment to providing high-quality biological products, our company leverages cutting-edge technology and expertise to deliver essential tools for advancing scientific understanding and fostering therapeutic breakthroughs.
Please note that all services are for research use only. Not intended for any clinical use.
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