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CHM Knockout Cell Lines

Gene: CHM

Official Full Name: CHM Rab escort proteinprovided by HGNC

Gene Summary: This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38562 CHM Knockout cell line (HeLa) Human CHM 1:3~1:6 Negative Online Inquiry
KO38563 CHM Knockout cell line (HCT 116) Human CHM 1:2~1:4 Negative Online Inquiry
KO38564 CHM Knockout cell line (HEK293) Human CHM 1:3~1:6 Negative Online Inquiry
KO38565 CHM Knockout cell line (A549) Human CHM 1:3~1:4 Negative Online Inquiry

Background

CHM Gene Knockout Cell Lines are specialized cellular models that have been genetically modified to lack the expression of specific target genes, thereby enabling researchers to investigate gene function, cellular pathways, and disease mechanisms with enhanced precision. These cell lines are developed through advanced CRISPR-Cas9 gene-editing technology, which allows for targeted and efficient disruption of genetic sequences, providing a powerful tool for both basic research and therapeutic development.

The key function of CHM Gene Knockout Cell Lines lies in their ability to reveal the role of the knocked-out gene by providing insights into alterations in cellular behavior, pathway activation, and phenotypic changes. By comparing knockout lines with their wild-type counterparts, scientists can assess the physiological and pathological consequences of gene deletion, facilitating studies in areas such as cancer biology, neurobiology, and metabolic disorders.

The scientific importance of CHM Gene Knockout Cell Lines cannot be overstated, as they serve as vital resources in both academic and clinical research settings. They play a crucial role in drug discovery by allowing for the identification of new targets and the assessment of therapeutic efficacy. Moreover, in translational research, these models enhance our understanding of human diseases by replicating genetic variants that contribute to complex traits and conditions.

Unique selling points of CHM Gene Knockout Cell Lines include their robust validation through comprehensive sequencing and functional assays, ensuring high fidelity in knockout efficiency. Compared to traditional knockout methods, such as RNA interference, these cell lines provide a more permanent and heritable alteration, yielding consistent and reproducible results that are essential for longitudinal studies.

For researchers and clinicians seeking reliable and versatile tools for gene function analysis, CHM Gene Knockout Cell Lines are invaluable. Their distinct ability to model specific genetic variations allows for more accurate experimentation and analysis, which translates into a stronger foundation for impactful scientific discoveries and therapeutic advancements.

Our company is committed to providing high-quality biological products supported by years of expertise in genetic engineering and cellular biology, ensuring that researchers have access to the latest tools for groundbreaking research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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