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CGGBP1 Knockout Cell Lines

Gene: CGGBP1

Official Full Name: CGG triplet repeat binding protein 1provided by HGNC

Gene Summary: This gene encodes a CGG repeat-binding protein that primarily localizes to the nucleus. CGG trinucleotide repeats are implicated in many disorders as they often act as transcription- and translation-regulatory elements, can produce hairpin structures which cause DNA replication errors, and form regions prone to chromosomal breakage. CGG repeats are also targets for CpG methylation. In addition to its ability to bind CGG repeats and regulate transcription, this gene is believed to play a role in DNA damage repair and telomere protection. In vitro studies indicate this protein does not bind to methylated CpG sequences. [provided by RefSeq, Jul 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34057 CGGBP1 Knockout cell line (HeLa) Human CGGBP1 1:3~1:6 Negative Online Inquiry
KO34058 CGGBP1 Knockout cell line (HCT 116) Human CGGBP1 1:2~1:4 Negative Online Inquiry
KO34059 CGGBP1 Knockout cell line (HEK293) Human CGGBP1 1:3~1:6 Negative Online Inquiry
KO34060 CGGBP1 Knockout cell line (A549) Human CGGBP1 1:3~1:4 Negative Online Inquiry

Background

CGGBP1 gene knockout cell lines are specifically engineered cellular models that lack the expression of the CGGBP1 gene, which encodes for the chromatin- and DNA-binding protein known as CGGBP1 (also termed cellular growth regulation protein). This product offers researchers a valuable tool to study the roles of CGGBP1 in cellular processes, such as gene regulation, DNA repair, and cellular responses to stress. By knockouting this gene, these cell lines facilitate the investigation of its contributions to various biological functions and disease mechanisms, particularly in cancer and immune responses.

The key function of CGGBP1 lies in its interaction with the chromatin landscape, where it regulates gene expression by modulating the accessibility of DNA to transcriptional machinery. The knockout of CGGBP1 allows for an in-depth understanding of its role in chromatin remodeling and its influence on cell cycle progression, proliferation, and apoptosis. Researchers can leverage these cell lines to elucidate how the absence of CGGBP1 impacts genomic stability and contributes to tumorigenesis or immune dysfunction.

From a scientific and clinical perspective, these knockout cell lines are pivotal for advancing knowledge in molecular biology, genetics, and oncology. They offer significant applications in understanding the underlying mechanisms of diseases and can potentially pave the way for developing targeted therapies. Unlike conventional cell lines, the specific knockout of CGGBP1 eliminates confounding factors related to gene expression variability, providing clearer insights into the biological pathways involved.

One of the standout advantages of our CGGBP1 gene knockout cell lines is their robust validation and reproducibility, ensuring reliability in experimental outcomes. Furthermore, they come with comprehensive documentation and support, making it easier for researchers to integrate them into their studies effectively. The unique selling point of this product lies not only in its specificity but also in the time saved for researchers who might otherwise have to generate these models from scratch.

Engaging with our CGGBP1 gene knockout cell lines empowers researchers and clinicians alike to drive innovation in their fields. Our commitment to quality and scientific rigor stems from years of expertise and dedication in producing biological research tools that foster advanced scientific inquiry.

Please note that all services are for research use only. Not intended for any clinical use.

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