Gene: CEP112
Official Full Name: centrosomal protein 112provided by HGNC
Gene Summary: This gene encodes a coiled-coil domain containing protein that belongs to the cell division control protein 42 effector protein family. In neurons, it localizes to the cytoplasm of dendrites and is also enriched in the nucleus where it interacts with the RNA polymerase III transcriptional repressor Maf1 to regulate gamma-aminobutyric acid A receptor surface expression. In addition, the protein has been identified as a component of the human centrosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37634 | CEP112 Knockout cell line (HeLa) | Human | CEP112 | 1:3~1:6 | Negative | Online Inquiry |
KO37635 | CEP112 Knockout cell line (HCT 116) | Human | CEP112 | 1:2~1:4 | Negative | Online Inquiry |
KO37636 | CEP112 Knockout cell line (HEK293) | Human | CEP112 | 1:3~1:6 | Negative | Online Inquiry |
KO37637 | CEP112 Knockout cell line (A549) | Human | CEP112 | 1:3~1:4 | Negative | Online Inquiry |
CEP112 Gene Knockout Cell Lines are meticulously engineered cellular models designed to investigate the functional roles of the CEP112 gene in cellular processes and disease mechanisms. Utilizing advanced CRISPR-Cas9 genome editing technology, these cell lines have been created to inactivate, or "knock out," the CEP112 gene, offering researchers a powerful tool to assess gene function and elucidate its contributions to various biological pathways.
The key function of CEP112 Gene Knockout Cell Lines lies in their ability to facilitate the study of the CEP112 protein's role in cellular signaling, stress responses, and potential implications in human diseases, including neurodegeneration and cancer. By utilizing these knockout lines, researchers can observe phenotypic changes, alterations in metabolic functions, and differential gene expression patterns, providing critical insights into how the absence of CEP112 affects cellular viability, proliferation, and interaction with other cellular components.
The scientific importance of these gene knockout cell lines is underscored by their applications in both fundamental and translational research. They serve as invaluable platforms for drug screening, pathway analysis, and the development of therapeutic strategies targeting the CEP112-related pathways. In clinical settings, insights gained from these studies could lead to improved understanding of disease mechanisms and the identification of novel biomarkers or therapeutic targets.
Compared to conventional cell lines or less specific gene knockdown approaches, CEP112 Gene Knockout Cell Lines exhibit distinct advantages, including precise gene inactivation, the stable nature of the knockout, and the ability to generate multiple knockout lines for comprehensive studies. Furthermore, these lines allow for reproducibility and reliability in scientific findings, essential components in advancing research rigor.
For researchers and clinicians alike, the value of CEP112 Gene Knockout Cell Lines is apparent; they not only enhance the understanding of cellular functions but also pave the way for significant advancements in the treatment of diseases linked to CEP112 dysregulation. Our company specializes in the development and provision of high-quality biological products, ensuring our clients have access to innovative tools that empower their research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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