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CDC14A Knockout Cell Lines

Gene: CDC14A

Official Full Name: cell division cycle 14Aprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34048 CDC14A Knockout cell line (HeLa) Human CDC14A 1:3~1:6 Negative Online Inquiry
KO34049 CDC14A Knockout cell line (HCT 116) Human CDC14A 1:2~1:4 Negative Online Inquiry
KO34050 CDC14A Knockout cell line (HEK293) Human CDC14A 1:3~1:6 Negative Online Inquiry
KO34051 CDC14A Knockout cell line (A549) Human CDC14A 1:3~1:4 Negative Online Inquiry

Background

CDC14A Gene Knockout Cell Lines are advanced biological models designed to facilitate the study of the CDC14A gene, which plays a crucial role in regulating cell cycle progression and mitotic exit. These cell lines have been genetically modified to disrupt the expression of the CDC14A gene, providing researchers with a unique tool to investigate the gene's function and its implications in cellular processes.

The primary function of the CDC14A gene is to encode a phosphatase that regulates various cellular activities, such as dephosphorylation of key proteins involved in cell cycle checkpoints. By utilizing CDC14A Gene Knockout Cell Lines, researchers can examine the downstream effects of the gene's disruption on cell proliferation, apoptosis, and other critical cellular mechanisms. This versatile tool enables scientists to delve deeper into the role CDC14A plays in cancer biology, as aberrations in cell cycle regulation are often linked to tumor development and progression.

In scientific research and clinical applications, these knockout cell lines hold significant value. They serve as essential models for testing potential therapeutic compounds that target cell cycle dysregulation in cancer. Moreover, they can assist in elucidating the molecular pathways affected by CDC14A, opening avenues for personalized medicine approaches that specifically address these pathways in various cancer types.

Unlike traditional cell lines, which may still express the CDC14A protein, our knockout variants eliminate its function entirely, allowing for clearer interpretation of experimental results. This specificity significantly reduces the risk of confounding factors that may obscure data interpretations in studies evaluating cell cycle regulation and associated pathologies.

For researchers and clinicians seeking to enhance their understanding of cell cycle dynamics and cancer biology, CDC14A Gene Knockout Cell Lines represent an invaluable asset. By contributing to a more comprehensive understanding of cellular mechanisms and disease states, these products offer a pathway to innovative therapeutic advancements. With years of expertise in genetic engineering and cell line development, our company is committed to providing exceptional tools that empower the scientific community in their quest for discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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