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CCNO Knockout Cell Lines

Gene: CCNO

Official Full Name: cyclin Oprovided by HGNC

Gene Summary: This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31992 CCNO Knockout cell line (HeLa) Human CCNO 1:3~1:6 Negative Online Inquiry
KO31993 CCNO Knockout cell line (HCT 116) Human CCNO 1:2~1:4 Negative Online Inquiry
KO31994 CCNO Knockout cell line (HEK293) Human CCNO 1:3~1:6 Negative Online Inquiry
KO31995 CCNO Knockout cell line (A549) Human CCNO 1:3~1:4 Negative Online Inquiry

Background

CCNO Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the CCNO gene (cyclin C) in human biology and disease. These cell lines have been genetically engineered to disrupt the expression of the CCNO gene, allowing researchers to investigate its role in cellular processes such as cell cycle regulation, proliferation, and differentiation. The knockout mechanism typically employs CRISPR-Cas9 technology or other gene-editing techniques to create stable and reproducible cell lines, thereby enabling rigorous experimental workflows.

The primary function of the CCNO knockout cell lines is to provide insights into the biological pathways modulated by the CCNO protein. By examining these knockout models, researchers can elucidate the consequences of CCNO loss, such as aberrant cell cycle progression or altered response to cellular stressors. This can be especially crucial in cancer research, where cyclins play significant roles in tumorigenesis and tumor progression. Furthermore, these cell lines serve as invaluable tools for drug discovery, allowing for targeted screening of therapeutic compounds that may restore normal function in cells with disrupted CCNO expression.

The scientific importance of these knockout cell lines extends beyond basic research; they can also be applied in translational studies that inform clinical practice. For instance, understanding how CCNO contributes to cancer stemness could lead to novel therapeutic strategies aimed at eradicating resilient cancer cell populations. Compared to traditional overexpression or wild-type models, CCNO gene knockout cell lines provide a more accurate simulation of gene loss in vivo, leading to results that are more likely to reflect physiological conditions.

The unique selling points of our CCNO gene knockout cell lines lie in their robust validation and the ease with which they can be incorporated into existing experimental frameworks. By utilizing these models, researchers and clinicians can save valuable time and resources, expediting their investigations while obtaining reliable data. Our commitment to quality ensures that each cell line is extensively characterized for key genetic and phenotypic traits, providing confidence in the results derived from their use.

In conclusion, our expertise in gene editing and cellular biology allows us to offer high-quality, validated CCNO gene knockout cell lines that are indispensable for advancing research in cancer biology and related fields. Partner with us to enhance your research capabilities and contribute to groundbreaking scientific discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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