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CCND2 Knockout Cell Lines

Gene: CCND2

Official Full Name: cyclin D2provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10100 CCND2 Knockout cell line (HEK293) Human CCND2 1:3~1:6 Negative Online Inquiry

Background

CCND2 Gene Knockout Cell Lines represent a cutting-edge tool designed for the study of the cyclin D2 gene, a crucial component of cellular cycles that regulates cell proliferation and differentiation. These genetically engineered cell lines are created through CRISPR-Cas9 technology, ensuring a precise knockout of the CCND2 gene, thus providing researchers an ideal model to investigate the biological functions and downstream effects of cyclin D2 loss in various cellular contexts.

The primary function of CCND2 Gene Knockout Cell Lines is to enable the dissection of the role of cyclin D2 in cell cycle regulation, apoptosis, and cancer progression. By eliminating the influence of CCND2, scientists can observe alterations in cell division, signaling pathways, and gene expression profiles, significantly advancing our understanding of the molecular mechanisms underlying diseases such as breast and prostate cancer, where CCND2 is often implicated.

The scientific importance of these knockout cell lines extends to their wide-ranging applications in both basic and translational research. They serve as vital platforms for drug screening, development of novel therapeutics, and biomarker discovery, facilitating insights into potential therapeutic targets within the cell cycle machinery. Furthermore, their utility in personalized medicine approaches makes them critical in understanding patient-specific responses to cancer therapies.

What sets our CCND2 Gene Knockout Cell Lines apart from alternatives is the rigorous validation of functionality and specificity, ensuring reliable experimental outcomes. Researchers can have confidence in the reliability of their data, significantly reducing variability caused by off-target effects common in other knockout systems.

In conclusion, these knockout cell lines are invaluable assets for researchers and clinicians dedicated to cancer biology and treatment innovations. By enabling detailed insights into the role of cyclin D2, they pave the way for breakthroughs that could transform therapeutic strategies. Our company stands at the forefront of biotechnological advancements, delivering innovative genetic models that empower the scientific community to make impactful discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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