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CCDC50 Knockout Cell Lines

Gene: CCDC50

Official Full Name: coiled-coil domain containing 50provided by HGNC

Gene Summary: This gene encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and postnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF)-mediated cell signaling. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21858 CCDC50 Knockout cell line (HeLa) Human CCDC50 1:3~1:6 Negative Online Inquiry
KO21859 CCDC50 Knockout cell line (HCT 116) Human CCDC50 1:2~1:4 Negative Online Inquiry
KO21860 CCDC50 Knockout cell line (HEK293) Human CCDC50 1:3~1:6 Negative Online Inquiry
KO21861 CCDC50 Knockout cell line (A549) Human CCDC50 1:3~1:4 Negative Online Inquiry

Background

CCDC50 Gene Knockout Cell Lines are genetically engineered cell lines in which the CCDC50 gene has been specifically disrupted, allowing for the in-depth study of its biological functions and associated pathways. This product provides an invaluable tool for researchers exploring the role of CCDC50 in cellular processes such as autophagy, cellular response to stress, and development, as well as its implications in various diseases.

The key mechanism by which these knockout cell lines operate involves the removal or disruption of the CCDC50 gene, which encodes a protein involved in membrane trafficking and cellular signaling. By utilizing techniques such as CRISPR/Cas9 gene editing, these cell lines enable researchers to effectively elucidate the physiological impact of CCDC50 loss, especially in the context of diseases like cancer, neurodegenerative disorders, and metabolic syndrome. The resulting phenotypic changes can be monitored through various assays, including apoptosis, cellular proliferation, and migration, thus providing critical insights into the gene's biology.

The scientific importance of CCDC50 Gene Knockout Cell Lines lies in their versatility for both basic and applied research. They are essential for understanding the gene’s function within complex biological systems, offering applications in drug discovery, gene therapy, and disease modeling. Furthermore, they serve as benchmarks for testing novel therapeutic strategies and compounds that target pathways influenced by CCDC50.

Compared to alternative approaches, such as RNA interference, knockout cell lines offer a stable and permanent solution to study gene function without the transient effects associated with knockdown techniques. This stability is crucial for long-term studies and contributes to the reliability of experimental data.

For researchers and clinicians alike, the availability of CCDC50 Gene Knockout Cell Lines opens avenues for groundbreaking discoveries and innovations in biomedical research. Their unique ability to elucidate complex gene functions positions them as invaluable assets in commercial and academic laboratories focused on unlocking the biological roles of critical genes.

Our company prides itself on delivering high-quality, precisely engineered biological products backed by extensive research and development expertise. We are committed to supporting the scientific community with cutting-edge tools that drive progress in genetic research and therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

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