Gene: CCBE1
Official Full Name: collagen and calcium binding EGF domains 1provided by HGNC
Gene Summary: This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans. [provided by RefSeq, Mar 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO23767 | CCBE1 Knockout cell line (A549) | Human | CCBE1 | 1:3~1:4 | Negative | Online Inquiry |
CCBE1 Gene Knockout Cell Lines are genetically engineered cell models specifically designed to study the functions and pathways associated with the Collagen and Calcium-Binding EGF Domains 1 (CCBE1) gene. By utilizing advanced CRISPR-Cas9 technology, these cell lines provide a precise mutation in the CCBE1 gene, rendering it non-functional. This knockout allows researchers to investigate the role of CCBE1 in various biological processes, particularly those related to cardiovascular development and lymphatic system function.
The key function of CCBE1 is its involvement in the regulation of vascular endothelial growth factors and lymphangiogenesis. Studies have shown that CCBE1 is crucial for early development, especially in the formation of blood and lymphatic vessels. By using CCBE1 knockout cell lines, researchers can elucidate the mechanisms by which CCBE1 mutations contribute to diseases such as lymphedema and other vascular disorders, enabling a deeper understanding of pathophysiological mechanisms.
In research and clinical settings, these cell lines serve as valuable tools in drug discovery and the development of therapeutic interventions. They allow for high-throughput screening of potential drug compounds targeting the pathological effects of CCBE1 deficiency, providing insights that could lead to novel treatment strategies. Moreover, the ability to control and model specific gene functions in vitro enhances the reproducibility and reliability of experimental results.
What sets CCBE1 Gene Knockout Cell Lines apart from alternative models is their precision and specificity. Unlike other knockout models that may have off-target effects or incomplete gene disruption, our cell lines offer a high level of fidelity in CCBE1 gene editing, ensuring that researchers can confidently interpret their findings. Additionally, our lines come with comprehensive user support and onboarding resources, making them readily accessible to both seasoned researchers and newcomers.
These CCBE1 Gene Knockout Cell Lines are an invaluable asset for researchers and clinicians aiming to advance their understanding of CCBE1 implications in human health. Developed by our team of molecular biologists and genetic engineers, who have extensive experience in creating cutting-edge genetic tools, our product reflects our commitment to innovation and excellence in biological research. By choosing our CCBE1 Gene Knockout Cell Lines, users are equipped with superior tools that significantly enhance their research capabilities and contribute to breakthroughs in the field of genetics and developmental biology.
Please note that all services are for research use only. Not intended for any clinical use.
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