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CAVIN4 Knockout Cell Lines

Gene: CAVIN4

Official Full Name: caveolae associated protein 4provided by HGNC

Gene Summary: This gene encodes a protein containing two coiled-coil regions. The encoded protein promotes Rho/ROCK (Rho-kinase) signaling in cardiac muscles cells, and may facilitate myofibrillar organization. [provided by RefSeq, Jun 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19050 CAVIN4 Knockout cell line (HCT 116) Human CAVIN4 1:2~1:4 Negative Online Inquiry
KO19051 CAVIN4 Knockout cell line (HEK293) Human CAVIN4 1:3~1:6 Negative Online Inquiry
KO19052 CAVIN4 Knockout cell line (A549) Human CAVIN4 1:3~1:4 Negative Online Inquiry

Background

CAVIN4 Gene Knockout Cell Lines are precisely engineered cellular models designed to facilitate the study of the CAVIN4 gene, which encodes a protein implicated in the regulation of caveolae formation in lipid rafts and cellular processes such as signaling, endocytosis, and membrane dynamics. Utilizing CRISPR-Cas9 technology, these cell lines provide a powerful tool for researchers to investigate the functional consequences of CAVIN4 depletion, offering a means to explore its role in various physiological and pathological contexts.

The key function of CAVIN4 involves its contribution to the structural integrity and functionality of caveolae—small invaginations in the plasma membrane. By knocking out the CAVIN4 gene, researchers can elucidate its detailed biological mechanisms, including how alterations in its activity may influence cellular processes such as lipid metabolism and cellular signaling pathways, potentially leading to advancements in understanding diseases like cancer, cardiovascular conditions, and metabolic disorders.

In both research and clinical settings, the availability of CAVIN4 Gene Knockout Cell Lines serves as an invaluable asset. These cell lines allow for high-throughput screening and the assessment of therapeutic targets, making them pivotal in drug discovery and mechanistic studies. Their precise knockout design ensures reproducibility and robustness in experiments.

Compared to traditional methods of gene silencing, such as RNA interference, the CAVIN4 Gene Knockout Cell Lines offer several advantages, including stable and permanent gene disruption and reduced off-target effects, which significantly enhance the reliability of experimental outcomes. This specificity allows researchers to derive more accurate conclusions regarding gene function and involvement in disease.

These cell lines are essential for researchers and clinicians alike, as they enable a deeper understanding of CAVIN4 in diverse biological contexts, ultimately aiding in the development of novel therapeutic strategies. Our company prides itself on its expertise in cellular models and genetic engineering, providing top-tier biological products tailored to advancing scientific research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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