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CASP7 Knockout Cell Lines

Gene: CASP7

Official Full Name: caspase 7provided by HGNC

Gene Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08335 CASP7 Knockout cell line (HeLa) Human CASP7 1:3~1:6 Negative Online Inquiry
KO08336 CASP7 Knockout cell line (HCT 116) Human CASP7 1:2~1:4 Negative Online Inquiry
KO08337 CASP7 Knockout cell line (HEK293) Human CASP7 1:3~1:6 Negative Online Inquiry
KO08338 CASP7 Knockout cell line (A549) Human CASP7 1:3~1:4 Negative Online Inquiry

Background

CASP7 Gene Knockout Cell Lines represent a critical tool in the field of genetic research, specifically targeting the research of apoptosis and cellular signaling pathways. These cell lines have been engineered to have a complete knockout of the CASP7 gene, which encodes for caspase 7, an essential cysteine protease involved in the execution phase of apoptosis. By enabling the study of cells lacking this key enzyme, researchers can probe the intricate mechanisms of programmed cell death and its implications in various diseases, including cancer and neurodegenerative disorders.

The primary mechanism of these cell lines revolves around the profound role of caspase 7 in mediating apoptosis through the cleavage of specific substrates, thus facilitating cell dismantling during programmed cell death. By utilizing CASP7 knockout cell lines, scientists can effectively understand how the absence of this protease affects cellular behavior, survival, and response to chemotherapeutic agents. This offers invaluable insights into cellular resilience, tumorigenesis, and potential pathways for therapeutic intervention.

The scientific importance of CASP7 Gene Knockout Cell Lines extends to both foundational and applied research, providing a robust platform for the discovery of novel therapeutic targets and the validation of drug efficacy. In clinical settings, studies employing these cell lines can pave the way for the development of innovative treatments aimed at re-initiating apoptosis in resistant cancer cells or regulating neurodegenerative processes.

What sets CASP7 Gene Knockout Cell Lines apart from alternative products is their precision and reliability, derived from meticulous gene-editing techniques that ensure a true knockout without off-target effects. This guarantees that research data is both accurate and reproducible, essential attributes in scientific studies.

For researchers and clinicians, the value proposition lies in the ability to deepen their understanding of cell death pathways and to potentially develop interventions that could ameliorate diseases linked to dysregulated apoptosis. Our company specializes in providing high-quality biological products, with a track record of excellence in gene editing that supports the leading-edge needs of the scientific community. We are committed to empowering research and innovation through our extensive portfolio of cell lines and genetic tools.

Please note that all services are for research use only. Not intended for any clinical use.

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