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CASKIN2 Knockout Cell Lines

Gene: CASKIN2

Official Full Name: CASK interacting protein 2provided by HGNC

Gene Summary: This gene encodes a large protein that contains six ankyrin repeats, as well as a Src homology 3 (SH3) domain and two sterile alpha motif (SAM) domains, which may be involved in protein-protein interactions. The C-terminal portion of this protein is proline-rich and contains a conserved region. A related protein interacts with calcium/calmodulin-dependent serine protein kinase (CASK). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19073 CASKIN2 Knockout cell line (HeLa) Human CASKIN2 1:3~1:6 Negative Online Inquiry
KO19074 CASKIN2 Knockout cell line (HCT 116) Human CASKIN2 1:2~1:4 Negative Online Inquiry
KO19075 CASKIN2 Knockout cell line (HEK293) Human CASKIN2 1:3~1:6 Negative Online Inquiry
KO19076 CASKIN2 Knockout cell line (A549) Human CASKIN2 1:3~1:4 Negative Online Inquiry

Background

CASKIN2 Gene Knockout Cell Lines are genetically engineered cell lines designed to facilitate the study of the CASKIN2 gene's role in cellular processes and its implications in various biological pathways. These knockout lines are derived using advanced CRISPR-Cas9 technology, which enables precise editing of the genome, allowing researchers to observe the effects of the absence of CASKIN2 on cellular functions, signaling pathways, and physiological responses.

The primary function of CASKIN2, a member of the CASK family of proteins, includes involvement in synaptic development and neuronal function. By utilizing CASKIN2 Gene Knockout Cell Lines, researchers can elucidate the gene's role in synaptic signaling, neurogenesis, and potential implications in neurodevelopmental disorders. The knockout model allows for a clear comparison against wild-type cells, providing insight into not only the direct effects of its absence but also compensatory mechanisms that may arise.

The scientific importance of CASKIN2 Gene Knockout Cell Lines is profound, as manipulation of specific genetic targets can reveal novel therapeutic pathways and identify targets for drug development, particularly in neurodegenerative diseases. Using these cell lines in research offers a controlled environment to study CASKIN2's interactions with other proteins and its impact on cellular environments, making them invaluable in translational research.

Compared to traditional methods for gene disruption, such as RNA interference, CASKIN2 Gene Knockout Cell Lines provide a permanent and stable alteration of the target gene. This stability allows for long-term studies and eliminates variability associated with transient knockdown techniques, enabling researchers to achieve more reliable results.

For researchers and clinicians focusing on genetics, neurobiology, or drug development, CASKIN2 Gene Knockout Cell Lines represent a pivotal tool that can accelerate discovery and enhance understanding of complex biological systems. Our company’s expertise in gene editing technologies ensures that our products meet the highest quality standards, providing researchers with reliable resources for cutting-edge science. By integrating our validated knockout cell lines into their studies, users can enhance their research outcomes while contributing to the overarching goal of advancing therapeutic modalities in neurobiology and beyond.

Please note that all services are for research use only. Not intended for any clinical use.

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