Gene: CARS2
Official Full Name: cysteinyl-tRNA synthetase 2, mitochondrialprovided by HGNC
Gene Summary: This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of cysteine to tRNA molecules. A splice-site mutation in this gene has been associated with a novel progressive myoclonic epilepsy disease with similar symptoms to MERRF syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO19077 | CARS2 Knockout cell line (HeLa) | Human | CARS2 | 1:3~1:6 | Negative | Online Inquiry |
KO19078 | CARS2 Knockout cell line (HCT 116) | Human | CARS2 | 1:2~1:4 | Negative | Online Inquiry |
KO19079 | CARS2 Knockout cell line (HEK293) | Human | CARS2 | 1:3~1:6 | Negative | Online Inquiry |
KO19080 | CARS2 Knockout cell line (A549) | Human | CARS2 | 1:3~1:4 | Negative | Online Inquiry |
CARS2 Gene Knockout Cell Lines are specifically engineered cellular models where the CARS2 gene has been inactivated, providing researchers with a powerful tool for studying gene function and gene regulation processes. These cell lines offer a unique opportunity to explore the biological roles of CARS2, which is known to encode a protein involved in the metabolism of amino acids and can influence cellular signaling pathways.
The primary mechanism of these knockout cell lines is through the disruption of the CARS2 gene’s coding sequence, leading to a complete loss of functional CARS2 protein. This targeted mutation enables scientists to investigate the downstream effects of CARS2 deficiency on cellular processes such as proliferation, differentiation, and response to stress. The ability to manipulate gene expression at this level facilitates the examination of various biological hypotheses, making these cell lines invaluable for experimental research.
The scientific importance of CARS2 Gene Knockout Cell Lines extends beyond basic research; they serve as essential models for investigating disease mechanisms, particularly in conditions where amino acid metabolism is disrupted, such as certain metabolic disorders and cancers. With the increasing emphasis on precision medicine, these cellular models can help identify novel therapeutic targets and biomarkers.
One of the significant advantages of our CARS2 Gene Knockout Cell Lines is their validation and characterization through robust genomic and phenotypic analyses, ensuring researchers can trust their results. Unlike alternative models that may rely on transient transfections or less stable knockdown approaches, our cell lines provide a stable and reliable platform for long-term experiments.
For researchers and clinicians, the implications of utilizing CARS2 Gene Knockout Cell Lines are profound, enabling them to bridge the gap between basic research and clinical applications. The knowledge gained from these studies can lead to breakthroughs in understanding diseases and paving the way for innovative treatments.
Our company prides itself on excellence in producing high-quality biological products, backed by extensive research and development expertise. We are committed to advancing scientific discovery by providing researchers with the reliable tools they need to drive their investigations forward.
Please note that all services are for research use only. Not intended for any clinical use.
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