Gene: CARD16
Official Full Name: caspase recruitment domain family member 16provided by HGNC
Gene Summary: Enables several functions, including CARD domain binding activity; cysteine-type endopeptidase inhibitor activity; and enzyme binding activity. Involved in cellular response to lipopolysaccharide; regulation of gene expression; and regulation of signal transduction. Part of protease inhibitor complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30778 | CARD16 Knockout cell line (HeLa) | Human | CARD16 | 1:3~1:6 | Negative | Online Inquiry |
KO30779 | CARD16 Knockout cell line (HEK293) | Human | CARD16 | 1:3~1:6 | Negative | Online Inquiry |
CARD16 Gene Knockout Cell Lines are innovative biological tools designed for the study of inflammation and immune response mechanisms mediated by the CARD16 gene. These cell lines are created through the targeted knockout of the CARD16 gene, which encodes a protein that plays a pivotal role in the regulation of innate immunity and inflammatory signaling pathways, particularly in response to pathogen-associated molecular patterns (PAMPs).
The primary function of CARD16 knockout cell lines is to facilitate the detailed investigation of cellular responses to pathogenic infections and inflammation. By removing the CARD16 gene, researchers can observe changes in cellular behavior, signaling cascades, and the activation of downstream inflammatory responses. This allows for the elucidation of the CARD16-dependent pathways, contributing to a broader understanding of the immune system's functioning.
Scientifically, CARD16 knockout cell lines hold significant importance in both research and clinical settings. They are invaluable for studying conditions such as autoimmune diseases, chronic inflammation, and sepsis, thereby providing insights into potential therapeutic targets. These cell lines can aid in drug discovery, particularly for novel anti-inflammatory agents, making them a crucial asset in translational medicine.
One of the distinctive advantages of CARD16 knockout cell lines is their precise gene-editing technology, which surpasses traditional methods that may result in off-target effects. This specificity increases the reliability of experimental results, ensuring that findings are attributable to the intended gene alteration. Furthermore, these cell lines are optimized for ease of use in various cellular assays, thereby reducing experimental variability.
The value of CARD16 Gene Knockout Cell Lines extends beyond mere utility; they enable researchers to draw meaningful conclusions about the role of CARD16 in health and disease. For clinicians and researchers alike, these tools empower the advancement of scientific knowledge and therapeutic development, addressing gaps in understanding immune responses.
Our company's extensive expertise in gene editing and cell line development ensures that our CARD16 Gene Knockout Cell Lines are of the highest quality, validated for robust performance in laboratory settings. We are committed to providing researchers with state-of-the-art biological products that drive discovery and innovation in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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