Gene: CAPN7
Official Full Name: calpain 7provided by HGNC
Gene Summary: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29268 | CAPN7 Knockout cell line (HeLa) | Human | CAPN7 | 1:3~1:6 | Negative | Online Inquiry |
KO29269 | CAPN7 Knockout cell line (HCT 116) | Human | CAPN7 | 1:2~1:4 | Negative | Online Inquiry |
KO29270 | CAPN7 Knockout cell line (HEK293) | Human | CAPN7 | 1:3~1:6 | Negative | Online Inquiry |
KO29271 | CAPN7 Knockout cell line (A549) | Human | CAPN7 | 1:3~1:4 | Negative | Online Inquiry |
CAPN7 Gene Knockout Cell Lines are genetically engineered cellular systems that have had the CAPN7 gene disrupted to study its function and roles in various biological processes. This innovative tool allows for the examination of the effects of CAPN7 loss, a member of the calpain family of cysteine proteases, which is implicated in cellular signaling, migration, and apoptosis. By employing CRISPR-Cas9 technology, these cell lines provide a precise alteration of the CAPN7 gene, creating a more reliable model for researchers investigating the downstream effects of calpain-mediated pathways.
The primary function of CAPN7 Gene Knockout Cell Lines lies in their ability to mimic a biological state with specific gene inactivation, facilitating the study of gene function in a controlled environment. Researchers can observe alterations in cellular behavior, such as changes in cell adhesion, morphology, and survival, as well as alterations in response to stimuli. This enables insights into diseases where CAPN7 may play a critical role, including certain cancers and neurodegenerative disorders.
Scientifically, these cell lines are invaluable, as they open new avenues for understanding calpain biology and its implications in health and disease. Their application extends to drug discovery, where screening for therapeutics targeting calpain pathways can be conducted more effectively. Additionally, they offer potential for translational research, bridging basic scientific inquiry with clinical application.
Compared to traditional knockout methods, our CAPN7 Gene Knockout Cell Lines stand out due to their high specificity and efficiency of gene disruption, minimizing off-target effects and enhancing reproducibility in experimental outcomes. This precision reduces variability, providing a clearer understanding of the role of CAPN7 in various physiological and pathological contexts.
For researchers and clinicians alike, investing in our CAPN7 Gene Knockout Cell Lines enables access to a state-of-the-art tool that enhances experimental rigor and supports groundbreaking research. Our company specializes in developing high-quality genetic models and is committed to advancing scientific discovery through innovative biological products tailored to meet the evolving needs of the research community. With our expertise, you can trust that you are receiving a product designed to facilitate significant scientific advancements and accelerate your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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