Gene: CAMLG
Official Full Name: calcium modulating ligandprovided by HGNC
Gene Summary: The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38702 | CAMLG Knockout cell line (HeLa) | Human | CAMLG | 1:3~1:6 | Negative | Online Inquiry |
KO38703 | CAMLG Knockout cell line (HCT 116) | Human | CAMLG | 1:2~1:4 | Negative | Online Inquiry |
KO38704 | CAMLG Knockout cell line (HEK293) | Human | CAMLG | 1:3~1:6 | Negative | Online Inquiry |
KO38705 | CAMLG Knockout cell line (A549) | Human | CAMLG | 1:3~1:4 | Negative | Online Inquiry |
CAMLG Gene Knockout Cell Lines are genetically engineered cell lines where the CAMLG gene has been specifically disrupted or rendered inoperative through precise genetic editing techniques. These cell lines are invaluable tools for researchers investigating the functional roles of the CAMLG gene in various biological processes, including cellular signaling pathways, immune response modulation, and disease pathogenesis.
The core mechanism of these knockout cell lines involves the use of CRISPR/Cas9 technology or siRNA methodologies to achieve an effective disruption of the CAMLG gene. By silencing the gene, researchers can observe the resultant phenotypic changes, delineating the gene's contributions to cellular behavior and interactions. This provides crucial insights into how alterations within this gene can affect normal cell function and contribute to disease states.
The scientific importance of CAMLG Gene Knockout Cell Lines is profound, as they enable rigorous investigation into the role of CAMLG in diseases such as cancer, autoimmune disorders, and cardiovascular diseases. Furthermore, these cell lines serve as valuable models in drug discovery and development, allowing for the screening of therapeutic compounds that target specific pathways influenced by CAMLG.
Unlike alternative gene knockout methods that may yield heterogeneous populations, CAMLG Gene Knockout Cell Lines offer consistency and reliability, facilitating reproducible experimental results. Additionally, their established genetic background ensures that experiments concentrate on the effects attributed solely to the CAMLG gene, minimizing confounding variables.
For researchers and clinicians alike, the ability to effectively manipulate and study the CAMLG gene signifies a powerful advancement in understanding its biological roles, providing the potential for novel therapeutic interventions. Thus, investing in CAMLG Gene Knockout Cell Lines not only enhances research capabilities but also promotes greater advancements in clinical applications.
With years of expertise in genetic engineering and a commitment to quality, our company provides state-of-the-art biological products that empower researchers to push the boundaries of scientific understanding and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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