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CAMK2G Knockout Cell Lines

Gene: CAMK2G

Official Full Name: calcium/calmodulin dependent protein kinase II gammaprovided by HGNC

Gene Summary: The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01327 CAMK2G Knockout cell line (HeLa) Human CAMK2G 1:3~1:6 Negative Online Inquiry
KO11820 CAMK2G Knockout cell line (HCT 116) Human CAMK2G 1:2~1:4 Negative Online Inquiry
KO11821 CAMK2G Knockout cell line (HEK293) Human CAMK2G 1:3~1:6 Negative Online Inquiry
KO11822 CAMK2G Knockout cell line (A549) Human CAMK2G 1:3~1:4 Negative Online Inquiry

Background

CAMK2G Gene Knockout Cell Lines are genetically engineered cell lines that have had the CAMK2G gene specifically inactivated or "knocked out." The CAMK2G gene encodes a subunit of calcium/calmodulin-dependent protein kinase II (CaMKII), an essential player in various cellular processes including synaptic plasticity, learning, and memory formation. By utilizing these knockout cell lines, researchers can more effectively study the specific roles of CAMK2G in cellular signaling pathways and its implications in neurological disorders.

The key function of these cell lines is to provide a model for understanding the effects of CAMK2G deficiency on cellular behavior. The mechanism involves the disruption of calcium signaling pathways mediated by CaMKII, allowing for in-depth analysis of downstream effects on neuronal function and development. By observing these alterations, scientists can glean insights into the molecular basis of conditions such as Alzheimer's disease and schizophrenia, thereby opening new avenues for therapeutic interventions.

The scientific importance of CAMK2G Gene Knockout Cell Lines is underscored by their practical applications in translational research settings, particularly for drug discovery targeting neurodegenerative diseases. They offer a unique in vitro system that reflects the complexities of CAMKII signaling without the confounding factors present in vivo.

What sets our CAMK2G Gene Knockout Cell Lines apart from alternatives is their superior specificity and reliability, achieved through advanced CRISPR/Cas9 gene-editing technologies. This precision ensures that researchers can obtain reproducible results that reflect the true functional implications of CAMK2G loss, eliminating the ambiguity associated with less refined gene knockouts.

For researchers and clinicians, these specialized cell lines are invaluable tools that facilitate the exploration of signaling mechanisms critical to brain function. They not only enhance the understanding of CaMKII's role in health and disease but also empower the development of targeted therapeutic strategies.

At [Your Company's Name], we pride ourselves on our cutting-edge gene-editing technologies and commitment to advancing cellular models essential for scientific progress. Our expertise in developing tailored biological products enables researchers to unlock new findings that could profoundly impact the field of neuroscience.

Please note that all services are for research use only. Not intended for any clinical use.

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