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CAD Knockout Cell Lines

Gene: CAD

Official Full Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotaseprovided by HGNC

Gene Summary: The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00894 CAD Knockout cell line (HeLa) Human CAD 1:3~1:6 Negative Online Inquiry

Background

CAD Gene Knockout Cell Lines are genetically engineered cell lines that have undergone targeted gene disruption to create a knockout phenotype. This method of gene inactivation enables researchers to investigate the functional consequences of specific genes, allowing for a better understanding of gene function and regulation within various biological contexts. By employing precise genomic editing techniques, such as CRISPR/Cas9, the CAD Gene Knockout Cell Lines provide an essential tool for functional genomics studies, enabling researchers to elucidate the roles of particular genes in cellular processes.

The key functions of these knockout cell lines include the ability to study gene expression, signaling pathways, and phenotypic outcomes following gene inactivation. The mechanisms by which these cell lines operate hinge on the disruption of gene coding sequences, leading to the loss of function, which can then be analyzed through various assays. By providing a model for disease studies, drug discovery, and basic biological research, CAD Gene Knockout Cell Lines enable scientists to dissect complex biological systems and identify potential therapeutic targets.

In the realm of scientific importance, these cell lines find applications in both research and clinical settings. Researchers are utilizing them to model disease mechanisms, assess drug efficacy, and investigate gene interactions. The knockouts allow for significant advancements in the understanding of genetic disorders, cancer biology, and metabolic diseases, paving the way for potential treatment strategies.

Compared to alternative genetic models, CAD Gene Knockout Cell Lines offer specific advantages such as their customization, ease of use, and reproducibility. Their well-characterized genetic backgrounds and established protocols facilitate expedited research timelines, reducing the time and resources necessary for investigating gene function. This provides researchers and clinicians with a more efficient pathway to unlocking biological insights.

Ultimately, CAD Gene Knockout Cell Lines represent a valuable resource for both academic researchers and pharmaceutical companies striving for breakthroughs in genetic research and therapeutic development. Our company specializes in providing high-quality biological products designed to enhance research capabilities. With a commitment to innovation and excellence, we aim to support the scientific community in their quest for discovery and understanding through precise and reliable tools.

Please note that all services are for research use only. Not intended for any clinical use.

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