Gene: BECN1
Official Full Name: beclin 1provided by HGNC
Gene Summary: This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00048 | Becn1 gRNA2 KO plasmid | Becn1 | $850 | |||
GP01458 | Becn1 gRNA1 KO plasmid | Becn1 | $850 |
BECN1 Gene Knockout Cell Lines are advanced biological tools developed to facilitate the study of autophagy and its implications in various diseases. These cell lines feature targeted deletions of the BECN1 gene, which encodes Beclin 1, a pivotal protein that initiates the autophagy process. Autophagy is a cellular degradation mechanism essential for maintaining homeostasis, particularly under stress conditions, and plays a significant role in cancer, neurodegenerative diseases, and infection responses.
The BECN1 knockout model serves as a valuable resource for researchers aiming to understand the molecular pathways and biological consequences of disrupted autophagy. By utilizing these cell lines, scientists can observe the phenotypic changes associated with reduced Beclin 1 function, including altered cell survival, proliferation, and metabolism. This enables a nuanced exploration of the therapeutic potential of autophagy modulation in clinical settings.
What sets our BECN1 Gene Knockout Cell Lines apart from alternatives is the meticulous validation process they undergo, ensuring high specificity and reliability. Users benefit from robust performance in a variety of experimental contexts, including drug screening, gene expression studies, and pathway analysis. These cell lines are also compatible with myriad assays, providing flexibility in research approaches.
The significance of BECN1 knockout cell lines transcends basic research; they empower clinicians and translational scientists to identify novel biomarkers and therapeutic targets, potentially leading to breakthroughs in treating a range of autophagy-related conditions. Engaging with our product equips researchers with the tools necessary to advance their studies in a field that is increasingly recognized for its therapeutic potential.
Our company brings years of expertise in creating high-quality biological models tailored to the needs of researchers and clinicians. We are dedicated to providing products like the BECN1 Gene Knockout Cell Lines, which are designed to enhance your research capabilities and contribute meaningfully to the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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