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BORCS8-MEF2B Knockout Cell Lines

Gene: BORCS8-MEF2B

Official Full Name: BORCS8-MEF2B readthroughprovided by HGNC

Gene Summary: This gene represents numerous read-through transcripts that span GeneID:729991 and 100271849. Many read-through transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some transcripts are predicted to be capable of translation reinitiation at a downstream AUG, resulting in expression of at least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is annotated on GeneID:100271849. [provided by RefSeq, Oct 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08380 BORCS8-MEF2B Knockout cell line (HCT 116) Human BORCS8-MEF2B 1:2~1:4 Negative Online Inquiry
KO08381 BORCS8-MEF2B Knockout cell line (A549) Human BORCS8-MEF2B 1:3~1:4 Negative Online Inquiry

Background

BORCS8-MEF2B Gene Knockout Cell Lines are sophisticated biological tools designed for the study of cellular processes and gene functions related to the BORCS8 and MEF2B genes. These cell lines have been engineered through CRISPR/Cas9 technology to achieve complete knockout of the target genes, enabling researchers to explore the phenotypic consequences of gene loss and the mechanistic pathways involved in various biological conditions.

The mechanism behind the functionality of these cell lines lies in the precision of the CRISPR/Cas9 editing system, which introduces double-strand breaks at specific genomic locations. This targeted approach efficiently disrupts the coding sequences of BORCS8 and MEF2B, leading to a lack of functional protein expression. The resultant cell lines serve as powerful models for investigating gene function, signaling pathways, and gene interactions in both normal physiological states and disease contexts.

Scientifically, the importance of BORCS8 and MEF2B knockout cell lines is vast. They are invaluable in research areas such as neurobiology, cancer biology, and cardiovascular studies, where both genes have been implicated in developmental processes and disease pathogenesis. By providing a model to study the loss-of-function effects of these genes, researchers can gain insights that contribute to the understanding of fundamental biological questions and therapeutic targets.

Compared to conventional gene disruption methods, the BORCS8-MEF2B Gene Knockout Cell Lines offer enhanced specificity and efficiency, reducing off-target effects and enabling quicker validation of results. These cell lines are also readily available and can be easily incorporated into existing research workflows, making them particularly advantageous for busy laboratories.

For researchers and clinicians focused on advancing genetic research and therapeutic development, these knockout cell lines are a strategic resource that can accelerate discoveries and provide significant insights into gene functions. Furthermore, our company, with extensive experience in developing cutting-edge biological products, stands behind the reliability and quality of the BORCS8-MEF2B Gene Knockout Cell Lines, ensuring that you have access to the best tools for your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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