Gene: BLVRB
Official Full Name: biliverdin reductase Bprovided by HGNC
Gene Summary: Enables biliverdin reductase [NAD(P)+] activity; peptidyl-cysteine S-nitrosylase activity; and riboflavin reductase (NADPH) activity. Involved in heme catabolic process; megakaryocyte differentiation; and negative regulation of insulin receptor signaling pathway. Located in cytosol; nucleoplasm; and plasma membrane. Is active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38805 | BLVRB Knockout cell line (HeLa) | Human | BLVRB | 1:3~1:6 | Negative | Online Inquiry |
KO38806 | BLVRB Knockout cell line (HCT 116) | Human | BLVRB | 1:2~1:4 | Negative | Online Inquiry |
KO38807 | BLVRB Knockout cell line (HEK293) | Human | BLVRB | 1:3~1:6 | Negative | Online Inquiry |
KO38808 | BLVRB Knockout cell line (A549) | Human | BLVRB | 1:3~1:4 | Negative | Online Inquiry |
BLVRB Gene Knockout Cell Lines are specifically engineered cellular models that enable the study of the BLVRB gene—an important component in the NADPH-dependent reduction of biliverdin into bilirubin, a process fundamental to cellular antioxidant defense and heme metabolism. These knockout cell lines provide a unique tool for researchers to investigate the functional roles of the BLVRB gene in cellular processes and disease mechanisms.
The key function of BLVRB Gene Knockout Cell Lines lies in their ability to mimic a loss-of-function scenario, enabling the exploration of BLVRB's contributions to oxidative stress responses, cell signaling, and metabolic regulation. Upon knockout, these cells exhibit altered responses to oxidative insults, facilitating the dissection of biochemical pathways that could be disrupted in various pathological conditions, such as neurodegeneration or metabolic disorders. This nuanced understanding is critical for developing targeted therapeutic strategies.
In scientific and clinical research settings, these knockout models are invaluable for elucidating the cellular mechanisms underlying diseases that involve oxidative damage and stress responses. Compared to traditional cell lines that may retain functional BLVRB, our gene knockout lines offer a cleaner, more specific approach to studying the gene's role without the confounding effects of residual activity. This specificity enhances the reproducibility and reliability of experimental results, critical for both basic research and therapeutic development.
One of the standout advantages of our BLVRB Gene Knockout Cell Lines is their ease of use in both in vitro and in vivo experimental contexts, offering flexibility in research designs. With robust validation processes, these specialized cell lines ensure consistency and integrity in experimental outcomes, empowering researchers to gain clearer insights into BLVRB's functions.
The value of BLVRB Gene Knockout Cell Lines extends beyond mere research tools; they enhance the capabilities of scientists and clinicians in pushing the boundaries of our understanding of oxidative stress and its implications in health and disease. Our commitment to quality and innovation informs our production process, ensuring that our cell lines are at the forefront of scientific exploration. With years of experience in biological product development, our company stands as a trusted partner in advancing research and therapeutic applications.
Please note that all services are for research use only. Not intended for any clinical use.
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