Gene: BEX2
Official Full Name: brain expressed X-linked 2provided by HGNC
Gene Summary: This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24696 | BEX2 Knockout cell line (HeLa) | Human | BEX2 | 1:3~1:6 | Negative | Online Inquiry |
KO24697 | BEX2 Knockout cell line (HCT 116) | Human | BEX2 | 1:2~1:4 | Negative | Online Inquiry |
KO24698 | BEX2 Knockout cell line (HEK293) | Human | BEX2 | 1:3~1:6 | Negative | Online Inquiry |
KO24699 | BEX2 Knockout cell line (A549) | Human | BEX2 | 1:3~1:4 | Negative | Online Inquiry |
BEX2 Gene Knockout Cell Lines are specialized cellular models designed for the systematic study of the BEX2 gene, known to play critical roles in neurodevelopment and cancer biology. These genetically modified cell lines contain targeted deletions of the BEX2 gene, allowing researchers to investigate the functional consequences of its absence. Through the use of CRISPR-Cas9 technology or similar gene-editing techniques, these knockout cell lines provide a robust platform for elucidating the biological pathways and mechanisms regulated by BEX2.
The key functions of BEX2 involve its influence on neuronal signaling and its involvement in tumorigenic processes. By employing these knockout cell lines, scientists can explore the effects of BEX2 disruption on cell proliferation, differentiation, and apoptosis, as well as its implications in various health conditions, from neurodegenerative diseases to cancers. The insights gained from these experiments are invaluable for advancing our understanding of disease mechanisms and developing targeted therapeutic strategies.
One of the standout advantages of BEX2 Gene Knockout Cell Lines is their specificity; they allow for the precise investigation of BEX2-related gene functions without the confounding influence of other genes. This precise targeting enables researchers to reduce noise in their experimental data, improving the reliability of their findings compared to traditional methods or less specific alternatives like RNA interference. Additionally, these cell lines are rigorously characterized and validated, ensuring their performance in experimental settings.
For researchers and clinicians alike, the BEX2 Gene Knockout Cell Lines offer a unique tool to push the boundaries of current knowledge, making them essential for those engaged in cutting-edge genetic, pharmaceutical, or therapeutic research. By understanding the role of BEX2, users can uncover novel intervention points, potentially leading to breakthroughs in treatment strategies.
Our company specializes in the development and provision of high-quality biological research tools, underpinned by years of expertise in gene editing technologies. We are dedicated to supporting the scientific community with products that foster innovation and discovery in the realm of molecular and cellular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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