Gene: BDH1
Official Full Name: 3-hydroxybutyrate dehydrogenase 1provided by HGNC
Gene Summary: This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00288 | BDH1 Knockout cell line (HEK293) | Human | BDH1 | 1:3~1:6 | Negative | Online Inquiry |
KO38823 | BDH1 Knockout cell line (HeLa) | Human | BDH1 | 1:3~1:6 | Negative | Online Inquiry |
KO38824 | BDH1 Knockout cell line (HCT 116) | Human | BDH1 | 1:2~1:4 | Negative | Online Inquiry |
KO38825 | BDH1 Knockout cell line (A549) | Human | BDH1 | 1:3~1:4 | Negative | Online Inquiry |
BDH1 Gene Knockout Cell Lines represent a crucial tool in molecular biology, specifically designed for the study of the BDH1 gene’s biological functions and regulatory mechanisms. These cell lines are engineered to have a complete absence of the BDH1 gene, effectively allowing researchers to dissect its role in various metabolic pathways, particularly in lipid metabolism and steroidogenesis.
The key functionality of these knockout cell lines lies in their ability to provide a controlled environment for assessing the physiological effects and compensatory mechanisms that occur when BDH1 expression is hindered. By utilizing CRISPR-Cas9 or similar gene editing technologies, the knockout cell lines enable precise investigations into the gene’s impact on cellular processes, such as energy production and fatty acid oxidation. This experimental setup is vital for elucidating the intricate pathways that underscore metabolic disorders and provides insights into potential therapeutic interventions.
The scientific importance of BDH1 Gene Knockout Cell Lines extends into both research and clinical settings. Researchers can use these models to explore the genetic basis of diseases associated with aberrant lipid metabolism, such as obesity, diabetes, and cardiovascular diseases, all of which remain critical public health challenges. Furthermore, these cell lines are instrumental in screening for drug candidates aimed at modulating BDH1-related pathways, making them valuable for translational research.
What sets BDH1 Gene Knockout Cell Lines apart from alternatives is their superior specificity and reliability. Designed with a comprehensive understanding of the BDH1 gene's interactions and pathways, these cell lines offer enhanced experimental reproducibility and can save researchers significant time and resources in their studies. Moreover, they come with robust technical support from our experienced team, ensuring that users can maximize their research outcomes.
For researchers and clinicians committed to advancing the understanding of metabolic diseases, BDH1 Gene Knockout Cell Lines are an essential addition to their experimental toolkit. Our company prides itself on its dedication to providing high-quality biological products, backed by our commitment to cutting-edge research and development. By choosing our product, users will leverage a resource developed with the intricacies of molecular biology in mind, enhancing the efficacy and impact of their research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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