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BCL7A Knockout Cell Lines

Gene: BCL7A

Official Full Name: BAF chromatin remodeling complex subunit BCL7Aprovided by HGNC

Gene Summary: This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38826 BCL7A Knockout cell line (HeLa) Human BCL7A 1:3~1:6 Negative Online Inquiry
KO38827 BCL7A Knockout cell line (HCT 116) Human BCL7A 1:2~1:4 Negative Online Inquiry
KO38828 BCL7A Knockout cell line (HEK293) Human BCL7A 1:3~1:6 Negative Online Inquiry
KO38829 BCL7A Knockout cell line (A549) Human BCL7A 1:3~1:4 Negative Online Inquiry

Background

BCL7A Gene Knockout Cell Lines are genetically engineered cell models designed to facilitate the study of the BCL7A gene, known for its pivotal role in cellular proliferation and the regulation of oncogenic processes. By employing CRISPR-Cas9 gene editing technology, these cell lines have been specifically modified to eliminate the expression of BCL7A, thus providing researchers with a tool to investigate the gene's function in various biological contexts and its implications in cancer biology.

The key mechanism behind these knockout cell lines involves the targeted disruption of the BCL7A gene, leading to the absence of the BCL7A protein. This allows researchers to observe downstream effects, including changes in cell cycle progression, apoptosis, and differentiation pathways. By analyzing these alterations, scientists gain insights into how BCL7A influences tumor genesis and progression, making it invaluable for cancer research.

The scientific importance of BCL7A Gene Knockout Cell Lines extends to their multifaceted applications in both basic and translational research. They are essential for exploring therapeutic targets, understanding tumor microenvironments, and validating potential pharmacological interventions aimed at reactivating suppressed pathways in malignancies. Furthermore, these cell lines serve as powerful tools for drug screening and biomarker discovery, supporting the development of personalized medicine approaches.

Compared to alternative models, such as overexpression or wild-type cell lines, the BCL7A Gene Knockout Cell Lines offer a unique advantage by allowing for the direct observation of loss-of-function effects. This specificity dramatically increases the relevance of experimental findings in relation to the gene's biological role in cancer progression.

For researchers and clinicians seeking to deepen their understanding of the underlying mechanisms of cancer, BCL7A Gene Knockout Cell Lines present an unparalleled opportunity to bridge basic research with clinical applications. The potential to uncover novel therapeutic strategies and enhance patient outcomes underscores the value of incorporating these advanced tools into research protocols.

At our company, we pride ourselves on our commitment to providing high-quality, innovative products that address the needs of the scientific community. Our expertise in gene editing technologies enables us to deliver reliable and effective cell lines that empower researchers to make significant advancements in their fields.

Please note that all services are for research use only. Not intended for any clinical use.

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