Gene: BAIAP2L1
Official Full Name: BAR/IMD domain containing adaptor protein 2 like 1provided by HGNC
Gene Summary: This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04087 | BAIAP2L1 Knockout cell line (HeLa) | Human | BAIAP2L1 | 1:3~1:6 | Negative | Online Inquiry |
KO04088 | BAIAP2L1 Knockout cell line (HCT 116) | Human | BAIAP2L1 | 1:2~1:4 | Negative | Online Inquiry |
KO04089 | BAIAP2L1 Knockout cell line (HEK293) | Human | BAIAP2L1 | 1:3~1:6 | Negative | Online Inquiry |
KO04090 | BAIAP2L1 Knockout cell line (A549) | Human | BAIAP2L1 | 1:3~1:4 | Negative | Online Inquiry |
BAIAP2L1 gene knockout cell lines are genetically engineered models specifically designed to study the function of the BAIAP2L1 gene, which is implicated in various cellular processes, including cytoskeletal dynamics and signal transduction. By utilizing CRISPR-Cas9 or other gene editing technologies, these cell lines result in the complete ablation of BAIAP2L1 expression, allowing researchers to investigate the gene's role in physiological and pathological states, such as cancer metastasis or neurodevelopmental disorders.
The primary function of these knockout cell lines lies in their ability to elucidate the molecular pathways regulated by BAIAP2L1. When the gene is disrupted, scientists can observe changes in cell morphology, migration, proliferation, and apoptosis. This approach provides a robust platform for screening potential therapeutic targets and understanding gene-gene interactions in cellular signaling networks.
The scientific importance of BAIAP2L1 knockout cell lines is profound, especially in research settings that focus on tumor biology and developmental processes. These models facilitate the investigation of how the loss of BAIAP2L1 affects cellular responses to external stimuli and its contribution to disease pathology. Furthermore, in clinical applications, they serve as a valuable tool for drug discovery and testing new therapeutic interventions by providing insights into the efficacy and mechanisms of action of various compounds.
Comparatively, BAIAP2L1 gene knockout cell lines offer distinct advantages over other models. Unlike traditional knockdown approaches, which only reduce gene expression and may lead to compensatory mechanisms, these knockout models provide a complete disruption of the gene, yielding more definitive insights. Additionally, they can be tailored to specific cell types relevant to the research question, thereby improving the physiological relevance of experimental outcomes.
The value of BAIAP2L1 gene knockout cell lines for researchers and clinicians is evident. By providing a powerful mechanism to explore the fundamental roles of the BAIAP2L1 gene, these models enhance our understanding of complex biological systems and may facilitate breakthroughs in targeted therapies and personalized medicine.
Our company prides itself on delivering high-quality, genetically modified cell lines, backed by extensive expertise in molecular biology and genetic engineering. With a commitment to advancing scientific research, we provide unparalleled support and resources to empower researchers and clinicians to achieve their objectives efficiently and effectively.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.